Results 21 to 30 of about 6,568,368 (244)

Echinococcus granulosus cyst fluid inhibits inflammatory responses through inducing histone demethylase KDM5B in macrophages

Parasites & Vectors, 2023
Background Echinococcus granulosus cyst fluid (EgCF) weakens macrophage inflammatory responses, thereby enabling the parasite to evade the immune system. However, the role of histone modification in this process remains to be explored. Methods The levels
Xiaopeng Wang, Ruolin Lin, Chunxue Fu, Chun Yang, Dan Dong, Xiangwei Wu, Xueling Chen, Lianghai Wang, Jun Hou   +8 more
doaj   +1 more source

EPRS1 correlates with malignant progression in hepatocellular carcinoma

Infectious Agents and Cancer, 2023
Background Glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is an aminoacyl-tRNA synthase involved in the pathology of cancer and other diseases. In this study, we investigated the carcinogenic function, potential mechanism, and clinical significance of EPRS1 ...
Chen Yang, Xiaofeng Yang, Chenghao Liu, Jun Hou, Xueling Chen, Lianghai Wang, Xiangwei Wu   +6 more
doaj   +1 more source

Effects of scoparone on non-alcoholic fatty liver disease revealed by RNA sequencing

Frontiers in Endocrinology, 2022
Scoparone (SCO) is known to have curative effect of alleviating liver injury. The purpose of this study was to observe the therapeutic effect and possible mechanism of SCO against high-fat diet (HFD) induced non-alcoholic liver disease (NAFLD) through in
Xiaoyan Huang, Xiaoyan Huang, Ya Gao, Ya Gao, Houkang Cao, Jun Li, Siyi Mo, Ting Li, Jianzhao Wu, Kai Guo, Riming Wei, Riming Wei, Kefeng Zhang, Kefeng Zhang   +13 more
doaj   +1 more source

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017 : a systematic analysis for the Global Burden of Disease Study 2017 [PDF]

, 2018
Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to ...
GBD 2017 Dis Injury Incidence Pr
core   +3 more sources

Predicting the long-term impact of antiretroviral therapy scale-up on population incidence of tuberculosis. [PDF]

, 2013
OBJECTIVE: To investigate the impact of antiretroviral therapy (ART) on long-term population-level tuberculosis disease (TB) incidence in sub-Saharan Africa. METHODS: We used a mathematical model to consider the effect of different assumptions about life
A Espinal M, A Gupta, A Van Rie, AB Suthar, AD Harries, B Zaba, BG Williams, D Nash, EL Corbett, Elizabeth L. Corbett, Gwenan M. Knight, H Getahun, Hiroshi Nishiura, J Stover, JE Golub, JE Golub, L Gras, M Cornell, MD Nglazi, MS Cohen, Peter J. Dodd, R Granich, R Zachariah, Richard G. White, SD Lawn, SD Lawn, SD Lawn, Stephen D. Lawn, T Samandari   +28 more
core   +10 more sources

CALM1 promotes progression and dampens chemosensitivity to EGFR inhibitor in esophageal squamous cell carcinoma

Cancer Cell International, 2021
Background Calmodulin1 (CALM1) has been identified as one of the overexpression genes in a variety of cancers and EGFR inhibitor have been widely used in clinical treatment but it is unknown whether CALM1 and epidermal growth factor receptor (EGFR) have ...
Tao Liu, Xiujuan Han, Shutao Zheng, Qing Liu, Aerziguli Tuerxun, Qiqi Zhang, Lifei Yang, Xiaomei Lu   +7 more
doaj   +1 more source

Bioinformatics-Based Identification of CircRNA-MicroRNA-mRNA Network for Calcific Aortic Valve Disease

Genetics Research, 2023
Background. Calcific aortic valve disease (CAVD) is the most common native valve disease. Valvular interstitial cell (VIC) osteogenic differentiation and valvular endothelial cell (VEC) dysfunction are key steps in CAVD progression.
Linghong Song, Yubing Wang, Yufei Feng, Hao Peng, Chengyan Wang, Juncang Duan, Kejian Liu, Xihua Shen, Wenyi Gu, Yan Qi, Shan Jin, Lijuan Pang   +11 more
doaj   +1 more source

Guide to Metabolomics Analysis: A Bioinformatics Workflow

Metabolites, 2022
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The key purpose of metabolomics is to identify the metabolites corresponding to each biological phenotype, and then provide an analysis of the mechanisms involved ...
Yang Chen, En-Min Li, Li-Yan Xu
doaj   +1 more source

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Ca, 2018
This article provides a status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across ...
F. Bray, J. Ferlay, I. Soerjomataram, R. Siegel, Lindsey A. Torre, A. Jemal   +5 more
semanticscholar   +1 more source

Mining Root Cause Knowledge from Cloud Service Incident Investigations for AIOps [PDF]

ICSE-SEIP 2022, 2022
Root Cause Analysis (RCA) of any service-disrupting incident is one of the most critical as well as complex tasks in IT processes, especially for cloud industry leaders like Salesforce. Typically RCA investigation leverages data-sources like application error logs or service call traces.
arxiv   +1 more source