Results 91 to 100 of about 659,420 (290)

Misalignment of the microquasar V4641 Sgr (SAX J1819.3--2525)

, 2008
In the microquasar V4641 Sgr the spin of the black hole is thought to be misaligned with the binary orbital axis. The accretion disc aligns with the black hole spin by the Lense-Thirring effect near to the black hole and further out becomes aligned with ...
Bardeen, Blandford, Brandt, Butt, Chaty, Fabian, Fabian, Garcia, Greene, Hjellming, Hjellming, in't Zand, in't Zand, J. E. Pringle, Laor, Maccarone, Maitra, Markwardt, Martin, Martin, Martin, Miller, Miller, Mirabel, Narayan, Nishikawa, Orosz, Orosz, Orosz, Pringle, Rebecca G. Martin, Reis, Revnivtsev, Reynolds, Reynolds, Rubens C. Reis, Scheuer, Shakura, Wijers, Zhang   +39 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Investigating the Qur’anic Wisdom through the Frameworks of Insights, Tendencies, and Actions in the Textbooks of Hadyahā-yi Āsmānī (Heavenly Gifts) for Elementary School [PDF]

مسائل کاربردی تعلیم و تربیت اسلامی
Objective: This study examines the Qur’anic wisdom through the frameworks of insights, tendencies, and actions presented in the textbooks of hadiyahā-yi āsmānī (heavenly gifts) for elementary school.
fatemeh Hajibabaei, Mohammad Sharifani, Hossein Moradi Zanjani   +2 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Analysis of Sway in Ballroom Dancing

Proceedings, 2018
According to syllabi of ballroom dancing, the sway is explained as the inclination of the body towards the inside of the turn. This explanation is questionable and a more adequate explanation is given based on a mechanical analysis with a new concept of ...
Tadashi Shioya
doaj   +1 more source

On the Apparent Orbital Inclination Change of the Extrasolar Transiting Planet TrES-2b

, 2010
On June 15, 2009 UT the transit of TrES-2b was detected using the University of Arizona's 1.55 meter Kuiper Telescope with 2.0-2.5 millimag RMS accuracy in the I-band.
Bakos, Borucki, Borucki, Butler, Dittmann, Dittmann, Elizabeth M. Green, Gilliland, Holman, Jared R. Males, Jason A. Dittmann, Koch, Laird M. Close, Louis J. Scuderi, Mandel, Miralda-Escudé, O'Donovan, Ribas   +17 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

On the Dynamical Stability of Gamma Cephei, an S-Type Binary Planetary System

, 2004
Precision radial velocity measurements of the Gamma Cephei (HR8974) binary system suggest the existence of a planetary companion with a minimum mass of 1.7 Jupiter-mass on an elliptical orbit with a ~2.14 AU semimajor axis and 0.12 eccentricity (hatzes ...
Haghighipour, Nader
core   +2 more sources