Results 71 to 80 of about 659,420 (290)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Formosan Journal of Musculoskeletal DisordersBackground: Postoperative leg length discrepancy (LLD) and dislocation are the most common complications after total hip replacement. Modern technology with three-dimensional (3D) planning can be very helpful for total hip arthroplasty to restore the ...
Meng-Hsueh Tsai +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
On the Dynamics of the Inclination Instability [PDF]
The Astronomical Journal, 2018 Abstract Axisymmetric disks of eccentric Kepler orbits are vulnerable to an instability that causes orbits to exponentially grow in inclination, decrease in eccentricity, and cluster in their angle of pericenter. Geometrically, the disk expands to a cone shape that is asymmetric about the mid-plane. In this paper, we describe how secular
Ann-Marie Madigan +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The relevance of prior inclination determination for direct imaging of Earth-like planets
, 2010 Direct imaging and characterization of extrasolar Earth-like planets is strongly impacted by the orbital inclination of the planet to be studied, as a combination of pure geometrical effects and the impact of exozodiacal dust.
Agol +33 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Static and Seismic Safety of the Inclined Tower of Portogruaro: A Preliminary Numerical Approach
BuildingsMasonry towers are peculiar structures with complex structural behavior despite biased conclusions deriving from their geometrical regularity and simplicity.
Rafael Shehu
doaj +1 more source
Scandinavian Journal of Work, Environment & Health, 2016 OBJECTIVES: This study aimed to investigate the association between forward bending of the trunk and low-back pain intensity (LBPi) among blue-collar workers in Denmark as well as whether the level of social support modifies the association.
Morten Villumsen +4 more
doaj +1 more source
Onset of Convection in an Inclined Anisotropic Porous Layer with Internal Heat Generation
Fluids, 2019 The onset of convection in an inclined porous layer which is heated internally by a uniform distribution of heat sources is considered. We investigate the combined effects of inclination, anisotropy and internal heat generation on the linear instability ...
Leiv Storesletten, D. Andrew S. Rees
doaj +1 more source