Results 91 to 100 of about 266,336 (265)

Carcinogen-DNA Adducts

, 2019
Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic ...
Arlt, Volker M.,, Krais, Annette M.,, Lund University., Singh, Rajinder,   +3 more
core   +1 more source

Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY). [PDF]

BackgroundWhile much research has been done to identify individual workplace lung carcinogens, little is known about joint effects on risk when workers are exposed to multiple agents.ObjectivesWe investigated the pairwise joint effects of occupational ...
Wichmann, Heinz-Erich, Demers, Paul A, Forastiere, Francesco, McLaughlin, John R, Schejbalova, Miriam, Vermeulen, Roel, Świątkowska, Beata, Pohlabeln, Hermann, Siemiatycki, Jack, Barul, Christine, Brüning, Thomas, Migliore, Enrica, Richiardi, Lorenzo, Field, John K, Lissowska, Jolanta, Janout, Vladimir, Pándics, Tamás, Mclaughlin, John, Consonni, Dario, Behrens, Thomas, Caporaso, Neil, Merletti, Franco, Straif, Kurt, Vlaanderen, Jelle, Ge, Calvin, Field, John, Olsson, Ann, Mates, Dana, Fabianova, Eleonora, Ahrens, Wolfgang, Zaridze, David, Landi, Maria Teresa, Bouaoun, Liacine, Kromhout, Hans, Foretova, Lenka, Caporaso, Neil E, Boffetta, Paolo, Demers, Paul, Peters, Susan, Field, John K., Gustavsson, Per, Karrasch, Stefan, Radoi, Loredana, Jöckel, Karl-Heinz, Schüz, Joachim, Kendzia, Benjamin, Fernández-Tardón, Guillermo   +46 more
core   +4 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Cancer prevention: epidemiology and perspectives.

, 1999
Following increases up until the late 1980s, some decline in cancer mortality has been observed in North America and in Western Europe. Approximately half the decline can be attributed to the levelling off in lung and other tobacco-related cancer ...
Levi, F.
core  

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility

Cadernos de Saúde Pública
Epidemiological studies have estimated that approximately 80% of all cancers are related to environmental factors. Individual cancer susceptibility can be the result of several host factors, including differences in metabolism, DNA repair, altered ...
Ana Hatagima
doaj   +2 more sources

Remediation of Organic Pollutant for Wastewater Treatment by Employing Sustainable Graphene Oxide/NiO‐ZrO2/Zeolite Ternary Composite Material

CleanMat, EarlyView.
Graphene oxide/NiO‐ZrO2/zeolite ternary composite was synthesized hydrothermally. Efficient adsorption of Congo red onto GO/NiO‐ZrO2/zeolite composite was studied. ABSTRACT The present study employs a novel method for the synthesis of graphene oxide (GO) based ternary composite utilized for the adsorption of Congo red (CR), an anionic dye molecule. The
Hidaya Narzary, Nituraj Mushahary, Bipul Das, Sanjay Basumatary   +3 more
wiley   +1 more source

Is DNA methylation the new guardian of the genome?

Molecular Cytogenetics, 2017
Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.
Robert M. Hoffman
doaj   +1 more source

The contribution of molecular epidemiology to the identification of human carcinogens: Current status and future perspectives

, 2013
Background: The use of biological-based markers of exposure, intermediate effect, outcome, and susceptibility has become standard practice in cancer epidemiology, which has contributed to identification of several carcinogenic agents.
Islami, F., Boffetta, P.
core   +1 more source

A Survival Epidemiology Framework for Oral and Oropharyngeal Cancer

Cancer Nexus, EarlyView.
ABSTRACT Oral and oropharyngeal cancer remains a major global public health burden, but the literature addressing this disease is still organized predominantly around who develops it rather than around what determines life after diagnosis. That imbalance is consequential because diagnosis initiates a new scientific problem.
Raphael E. Cuomo
wiley   +1 more source