Results 81 to 90 of about 268,946 (224)

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Climate changes and cancer risk: Key factors and emerging health threats

Hygiene and Environmental Health Advances
Climate change, driven by global warming and environmental degradation, has far-reaching implications for human health, including its potential role in cancer incidence.
Marina Rayciki Sotomayor, Aline Graciele Henriques Campos, Altair Rodrigues Pires de Paula Filho, Ana Carolina Aredes Goulart, Beatriz Geovana Leite Vacario, Julia Fernandes Gois Orrutéa, Juliana Maria Bitencourt de Morais Valentim, Tatiane Renata Fagundes, Shaiane Carla Gaboardi, Carolina Panis   +9 more
doaj   +1 more source

Is DNA methylation the new guardian of the genome?

Molecular Cytogenetics, 2017
Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.
Robert M. Hoffman
doaj   +1 more source

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Cancer Chemoprevention by Traditional Chinese Herbal Medicine and Dietary Phytochemicals: Targeting Nrf2-Mediated Oxidative Stress/Anti-Inflammatory Responses, Epigenetics, and Cancer Stem Cells

Journal of Traditional and Complementary Medicine, 2013
Excessive oxidative stress induced by reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive metabolites of carcinogens alters cellular homeostasis, leading to genetic/epigenetic changes, genomic instability, neoplastic ...
Jong Hun Lee, Limin Shu, Francisco Fuentes, Zheng-Yuan Su, Ah-Ng Tony Kong   +4 more
doaj   +1 more source

Free Phenolic Hydroxyl Groups Govern the Anticancer Activity of α‐Mangostin: A Structure–Activity Relationship Insight

ChemFoodChem, EarlyView.
Free phenolic hydroxyl groups in the chemical structure of the natural xanthone α‐mangostin (MGT) contribute positively to achieving the anticancer profile against murine colon cancer, murine triple negative breast cancer, and human osteosarcoma cancer. ABSTRACT The α‐mangostin (MGT) is a natural xanthone obtained from the pericarp of mangosteen fruit (
Otávio Augusto Chaves, Afonso Santine M. M. Velez, Lívia Stenico, Douglas Chaves de Alcântara Pinto, Debora Decote‐Ricardo, Eliezer Avila Gandra, Marco Edilson Freire de Lima, Carlos Serpa   +7 more
wiley   +1 more source

Association Study of Polymorphism in CYP3A5 Gene with Bladder Cancer

Armaghane Danesh Bimonthly Journal, 2015
Aims and objectives: The environmental procarcinogen hypothesis of tumour pathogenesis proposes that many carcinogens require metabolic activation by drug metabolizing enzymes to form the proximate carcinogen.
m bakhtiari tajar, Kh Onsory, p shadpoor, m zafarmand   +3 more
doaj  

Remediation of Organic Pollutant for Wastewater Treatment by Employing Sustainable Graphene Oxide/NiO‐ZrO2/Zeolite Ternary Composite Material

CleanMat, EarlyView.
Graphene oxide/NiO‐ZrO2/zeolite ternary composite was synthesized hydrothermally. Efficient adsorption of Congo red onto GO/NiO‐ZrO2/zeolite composite was studied. ABSTRACT The present study employs a novel method for the synthesis of graphene oxide (GO) based ternary composite utilized for the adsorption of Congo red (CR), an anionic dye molecule. The
Hidaya Narzary, Nituraj Mushahary, Bipul Das, Sanjay Basumatary   +3 more
wiley   +1 more source

Risk assessment using IEUBK model for the Naica mine tailings

Environmental Progress &Sustainable Energy, EarlyView.
Abstract Mexico has a long history of mineral extraction, during which limited environmental regulations allowed the accumulation of toxic waste near communities, primarily in rural or undeveloped areas. Some of these toxic substances, such as lead, pose significant risks to vulnerable populations, particularly children aged 0 to 7 years.
A. Contreras‐Guardiola, M. A. Olmos‐Márquez, L. Cortés‐Palacios, E. Santellano‐Estrada, M. C. Valles‐Aragón   +4 more
wiley   +1 more source