Results 61 to 70 of about 266,336 (265)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

DNA adducts in human tissues:biomarkers of exposure to carcinogens in tobacco smoke [PDF]

, 1996
Tobacco smoking causes millions of cancer deaths annually. Tobacco smoke is a complex mixture of thousands of chemicals including many known animal carcinogens. Because many carcinogens from DNA adducts in target animal or human tissues, the detection of
Phillips, D H
core   +2 more sources

Application of the key characteristics of carcinogens in cancer hazard identification

, 2018
Smith et al. (Env. Health Perspect. 124: 713, 2016) identified 10 key characteristics (KCs), one or more of which are commonly exhibited by established human carcinogens.
dIRAS RA-1, Guyton, Kathryn Z., One Health Toxicologie, David C Christiani, Martyn T Smith, Matthew K Ross, Christiani, David C., van den Berg, Martin, Chiu, Weihsueh A., Christiani, David, Ivan Rusyn, Rusyn, Ivan, Kathryn Z Guyton, Guyton, Kathryn Z, Chiu, Weihsueh A, Weihsueh A Chiu, Smith, Martyn T, Smith, Martyn T., Beland, Frederick A, Ross, Matthew K, Frederick A Beland, Denis E Corpet, Martin van den Berg, Ross, Matthew K., Corpet, Denis E, Beland, Frederick A., Corpet, Denis E.   +26 more
core   +1 more source

Ban Glyphosate—Does It Affect the Swedish Farmers' Willingness to Grow Cover Crops?

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The cultivation of cover crops is one of the new Eco‐scheme practices introduced in Sweden. This study examines how the design of policy attributes of these schemes influences farmers' willingness to grow cover crops on arable land, with particular focus on the potential impact of a glyphosate ban.
Vivian Wei Huang, Anna Kristina Edenbrandt, Elin Röös   +2 more
wiley   +1 more source

The effects of cigarette smoking extracts on cell cycle and tumor spread: novel evidence

Future Science OA, 2019
Cigarette smoking is a major preventable risk factor for lung cancer, contributing to lung cancer progression and metastasis. Moreover, cigarette smoking correlates with increased metastasis frequency of pancreatic, breast and bladder cancer.
Aldo Pezzuto, Fabrizio Citarella, Ivana Croghan, Giuseppe Tonini   +3 more
doaj   +1 more source

Abstract 5742: Identifying likely breast carcinogens using complementary mechanistic approaches

, 2017
Many commercial chemicals and environmental pollutants show chemical or mechanistic similarity with known breast carcinogens such as ionizing radiation, hormones, alcohol, and tobacco. Regulatory agencies like the US Environmental Protection Agency (EPA)
Ruthann A. Rudel, Julia G. Brody, Megan R. Schwarzman, Janet M. Ackerman   +3 more
core   +1 more source

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Rare malignancies in Eastern India, socio-economic impact

Rare Tumors, 2016
The etiology of cancer is multifactorial. Various factors, including physical carcinogens, chemicals and viral carcinogens affect patients with known predisposing factors who subsequently develop malignancies. Here is a retrospective study of 18 patients
Surendra Senapati, Diptirani Samanta, Saumyaranjan Mishra, Chaitali Bose   +3 more
doaj   +1 more source

Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran. [PDF]

PLoS ONE, 2011
Golestan Province in northeastern Iran has one of the highest incidences of esophageal squamous cell carcinoma (ESCC) in the world with rates over 50 per 100,000 person-years in both sexes. We have analyzed TP53 mutation patterns in tumors from this high-
Behnoush Abedi-Ardekani, Farin Kamangar, Masoud Sotoudeh, Stephanie Villar, Farhad Islami, Karim Aghcheli, Dariush Nasrollahzadeh, Noushin Taghavi, Sanford M Dawsey, Christian C Abnet, Stephen M Hewitt, Saman Fahimi, Farrokh Saidi, Paul Brennan, Paolo Boffetta, Reza Malekzadeh, Pierre Hainaut   +16 more
doaj   +1 more source

Preventing hereditary cancers caused by opportunistic carcinogens [PDF]

, 2011
Objectives Previous studies reported inherited BRCA1/2 deficits can cause cancer by impairing normal protective responses. Opportunistic carcinogens can exploit these deficits by causing chronic inflammation, constant cell death and ...
Bernard Friedenson
core   +1 more source