Results 51 to 60 of about 302,282 (265)

Trends in bronchoscopic findings over a decade [PDF]

, 2009
The incidence of lung cancer in Maltese males is higher than that in females. However trends in Maltese and other foreign populations indicate a substantial recent increment in the diagnosis of lung cancer in women.
Agius, Maria, Falzon, Stephanie, Meli, Alexia, Micallef, Josef, Montefort, Stephen   +4 more
core  

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Summary of Workshop to Review an OMB Report on Regulatory Risk Assessment and Management [PDF]

, 1992
Summary of the results of an invitational workshop conducted to peer review the 1990 OMB report, CURRENT REGULATORY ISSUES IN Risk ASSESSMENT AND Risk MANAGENMENTIN REGULATORY PROGRAM OF THE UNITED STATES GOVERNMENT, APRIL 1, 1990 - MARCH 31 ...
Evans, John S., Graham, John D., Gray, George M., Hollis, Adrienne   +3 more
core   +2 more sources

Reaction time and incident cancer: 25 years of follow-up of study members in the UK Health and Lifestyle Survey [PDF]

, 2014
<b>Objectives</b><p></p> To investigate the association of reaction time with cancer incidence.<p></p> <b>Methods</b><p></p> 6900 individuals aged 18 to 94 years who participated in the
B Secretan, BA Shipley, BA Shipley, Beverly A. Roberts, CL Hart, CL Hart, CM Calvin, CR Gale, Dominika Dykiert, E Whitley, G. David Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, Geoff Der, Ian J. Deary, IJ Deary, IJ Deary, NP Walker, Suminori Akiba, T Chandola, T Hemmingsson, T Hemmingsson   +30 more
core   +3 more sources

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Geochemistry and risk assessment of street dust in Luanda, Angola, a tropical urban environment [PDF]

, 2005
A total of 92 samples of street dust were collected in Luanda, Angola, were sieved below 100 μm, and analysed by ICP-MS for 35 elements after an aqua-regia digestion.
Ferreira Baptista, Lopes, Miguel García, Eduardo de   +1 more
core   +2 more sources

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Detection of HPV in cancerous and non-cancerous esophageal tissues from Turkmen-Sahra, Iran [PDF]

, 2006
The aim of this study were to assess the presence of HPV esophageal infection among Iranian Turkmen who live in an area located in the cancer belt in Asia. The specimens derived from 120 patients previously diagnosed for Squamous Cell Carcinoma (SCC) non-
Mokhtari-Azad, T., Moradi, A.
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Carcinogenesis Associated with Toxin Nephropathy: Proposed Mediation by Phosphate Toxicity

Cells
Although cancer is often considered a genetic disease, genotoxic damage to nuclear DNA caused by carcinogens is not always sufficient to stimulate cancer cell growth, suggesting that other etiological factors are involved.
Ronald B. Brown, John G. Mielke
doaj   +1 more source