Results 41 to 50 of about 266,336 (265)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers

, 2022
Consumption of cruciferous vegetables, rich in the isothiocyanate glucoraphanin, is associated with reduced risk of tobacco-related cancers. Sulforaphane, released by hydrolysis of glucoraphanin, potently induces cytoprotective phase II enzymes ...
H.-H. Sherry Chow, Malgorzata Wojtowicz, Hsu, C.-H., Garland, L.L., Centuori, Sara, Eva Szabo, Julie E. Bauman, Guillen-Rodriguez, J., Sherry Chow, H.-H., Jose Guillen-Rodriguez, Bengtson, L., Padi, M., Bengtson, Lisa, Linda L. Garland, Szabo, Eva, Lisa Bengtson, Emily Ho, Bageerathan, V., Bauman, Julie E., Padi, Megha, Centuori, S., Wojtowicz, M., Szabo, E., Bageerathan, Vignesh, Chiu-Hsieh Hsu, Bauman, J.E., Megha Padi, Ho, E., Sara Centuori, Hsu, Chiu-Hsieh, Chow, H.-H. Sherry, Wojtowicz, Malgorzata, Vignesh Bageerathan, Guillen-Rodriguez, Jose, Garland, Linda L., Ho, Emily   +35 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Epigenetic mechanisms in metal carcinogenesis

Toxicology Reports, 2022
Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings.
Luka Manić, David Wallace, Pinar Uysal Onganer, Yasmeen M. Taalab, Ammad Ahmad Farooqi, Biljana Antonijević, Aleksandra Buha Djordjevic   +6 more
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer

, 2016
[[abstract]]PURPOSE: Allergy symptoms have been associated with a reduced head and neck cancer (HNC) risk, while elevated blood immunoglobulin E (IgE) levels have been associated with an increased HNC risk.
Liao, HC;Wu, SY;Ou, CY;Hsiao, JR;Huang, JS;Tsai, ST;Huang, CC;Wong, TY;Lee, WT;Chen, KC;Fang, SY;Wu, JL;Huang, TT;Wu, YH;Hsueh, WT;Yen, CJ;Yang, MW;Lin, FC;Lai, YH;Chang, JY;Lin, CL;Wang, YH;Weng, YL;Yang, HC;Chen, YS;Chang, JS
core   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Foodborne Carcinogens: Formation Pathways, Health Risks, and Cutting‐Edge Physical and Chemical Prevention Strategies

eFood
Food processing methods, though vital for improving food safety, taste, and shelf life, can unintentionally generate harmful carcinogens. Notable compounds such as acrylamide, heterocyclic amines, polycyclic aromatic hydrocarbons, nitrosamines, and lipid
Naglaa S. Ashmawy, Ahmed A. Zaky, Noha H. Badr, Ali Korin, Mohamed A. Farag   +4 more
doaj   +1 more source

Occupational cancers – Epidemiology and certification

Medycyna Pracy, 2018
The etiology of cancer is multifactorial. Malignant tumors caused by factors occurring in the work environment, classified as carcinogenic in humans, can be recognized as an occupational disease.
Marta Wiszniewska, Agnieszka Lipińska-Ojrzanowska, Anna Witkowska, Diana Tymoszuk, Aneta Kleniewska, Dariusz Kluszczyński, Jolanta Walusiak-Skorupa   +6 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source