Results 21 to 30 of about 266,336 (265)

Some chemical carcinogens for leukaemia induction and their animal models [PDF]

, 2019
Animal models have been providing invaluable contributions to the better understanding of mechanisms of cancer (including leukaemias) development and effectiveness of most of the treatments. Chemical carcinogens are generally used to study the biology of
Mustapha, Noordin Mohamed, Shaari, Mohd Rosly, Aliyu, Abdullahi, Ahmad Sayuti, Nurul Syahirah, Reduan, Mohd Farhan Hanif, Hamzah, Hazilawati, Sithambaram, Shanmugavelu, Shaari, Khozirah   +7 more
core   +1 more source

Clinical encounter with three cancer patients affected by groundwater contamination at Camp Lejeune: a case series and review of the literature

Journal of Medical Case Reports, 2022
Background Advanced understanding of tumor biology has recently revealed the complexity of cancer genetics, intra/inter-tumor heterogeneity, and diverse mechanisms of resistance to cancer treatment.
Kyungsuk Jung, Aziz Khan, Robert Mocharnuk, Susan Olivo-Marston, Justin T. McDaniel   +4 more
doaj   +1 more source

Squamous Cancer of the Esophagus in Africa: A Causal Pathway Established

Asian Pacific Journal of Cancer Biology, 2022
Squamous cancer of the esophagus has been endemic in much of East, Central and Southern Africa since the 1940s. Much research has concentrated on attempts to identify major carcinogenic influences, and failure to do so has made it clear that the problem ...
Alastair M Sammon
doaj   +1 more source

Characterisation of the p53-Mediated Cellular Responses Evoked in Primary Mouse Cells Following Exposure to Ultraviolet Radiation [PDF]

, 2013
Exposure to ultraviolet (UV) light can cause significant damage to mammalian cells and, although the spectrum of damage produced varies with the wavelength of UV, all parts of the UV spectrum are recognised as being detrimental to human health ...
McFeat, Gillian, Trevor J McMillan, McMillan, Trevor, Allinson, Sarah, Gillian D McFeat, Sarah L Allinson   +5 more
core   +1 more source

DNA Methylation as a Molecular Mechanism of Carcinogenesis in World Trade Center Dust Exposure: Insights from a Structured Literature Review

Biomolecules
The collapse of the World Trade Center (WTC) buildings in New York City generated a large plume of dust and smoke. WTC dust contained human carcinogens including metals, asbestos, polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants ...
Stephanie Tuminello, Nedim Durmus, Matija Snuderl, Yu Chen, Yongzhao Shao, Joan Reibman, Alan A. Arslan, Emanuela Taioli   +7 more
doaj   +1 more source

Establishing a Policy Framework for the Primary Prevention of Occupational Cancer: A Proposal Based on a Prospective Health Policy Analysis

Safety and Health at Work, 2017
Background: Despite our knowledge of the causes of cancer, millions of workers are involuntarily exposed to a wide range of known and suspected carcinogens in the workplace. To address this issue from a policy perspective, we developed a policy framework
Amanda Veglia, Manisha Pahwa, Paul A. Demers   +2 more
doaj   +1 more source

Relationship between Lung Carcinogenesis and Chronic Inflammation in Rodents

, 2021
Lung cancer remains the leading cause of cancer-related deaths, with an estimated 1.76 million deaths reported in 2018. Numerous studies have focused on the prevention and treatment of lung cancer using rodent models. Various chemicals, including tobacco-
Yuko Nakano-Narusawa, Yoko Matsuda, Misa Tanimoto, Keiko Yamakawa, Masanao Yokohira, Juanjuan Ye, Yuri Mukai, Katsumi Imaida, Linxuan Wu   +8 more
core   +1 more source

Synthetic Receptors for Early Detection and Treatment of Cancer

Biosensors, 2023
Over recent decades, synthetic macrocyclic compounds have attracted interest from the scientific community due to their ability to selectively and reversibly form complexes with a huge variety of guest moieties. These molecules have been studied within a
Frank Davis, Séamus P. J. Higson
doaj   +1 more source

The nuclear membrane in multidrug resistance: microinjection of epirubicin into bladder cancer cell lines

, 2005
Objevtive: to assess whether microinjecting epirubicin into cells showing multidrug resistance (MDR, common to many cancers, including bladder cancer, with resistance to, e.g.
Birch, B.R, Hayes, C.M, Featherstone, J.F, Cooper, A.J, Speers, A.G, Lwaleed, B.A   +5 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source