Results 81 to 90 of about 260,941 (267)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

In silico analysis of molecular docking between nicotine and GSTP1 gene in oral squamous cell carcinoma

Trakya University Journal of Natural Sciences
Oral squamous cell carcinoma (OSCC) is a predominant cancer strongly associated with risk factors like use of tobacco, viral infections, and genetic predispositions.
Shashanka Thowdanahalli Munipapanna, Prabhudas Nelaturi   +1 more
doaj   +1 more source

Small-cell lung cancer

Nature Reviews Disease Primers, 2021
C. Rudin, E. Brambilla, C. Faivre-Finn, J. Sage   +3 more
semanticscholar   +1 more source

Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer

Cancers, 2017
Lung cancer is the leading cause of deaths resulting from cancer owing to late diagnosis and limited treatment intervention. MicroRNAs are short, non-coding RNA molecules that regulate gene expression post-transcriptionally by translational repression or
K. Inamura
semanticscholar   +1 more source

Serum Bile Acids Are Useful Indicators of Intrahepatic Recurrence After Initial Curative Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Bile acids accumulation in hepatocytes causes liver damage and contributes to the development of hepatocellular carcinoma. However, the association between serum bile acid levels and postoperative intrahepatic recurrence in hepatocellular carcinoma remains unclear.
Tomoaki Bekki, Masahiro Ohira, Yuki Imaoka, Seiichi Simizu, Tomoyuki Abe, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan   +9 more
wiley   +1 more source

Twenty‐Year Longitudinal Cohort Study of Cancer Incidence and Mortality Among Workers in Two Primary Aluminum Prebake Smelters

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Classified as carcinogenic to humans by the International Agency for Research on Cancer, aluminum production has been transitioning towards lower polycyclic aromatic hydrocarbon‐emitting prebake smelters. This study explored the risk of cancer and mortality over 20 years follow‐up among a cohort of aluminum prebake smelter workers ...
Natasha Kinsman, Christina Dimitriadis, Anthony Del Monaco, Geza Benke, Sophia Xie, Malcolm Sim, StellaMay Gwini, Karen Walker‐Bone   +7 more
wiley   +1 more source

Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility

Cadernos de Saúde Pública
Epidemiological studies have estimated that approximately 80% of all cancers are related to environmental factors. Individual cancer susceptibility can be the result of several host factors, including differences in metabolism, DNA repair, altered ...
Ana Hatagima
doaj   +2 more sources

Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention

Nature Reviews. Cancer, 2022
S. Hecht, D. Hatsukami
semanticscholar   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Climate changes and cancer risk: Key factors and emerging health threats

Hygiene and Environmental Health Advances
Climate change, driven by global warming and environmental degradation, has far-reaching implications for human health, including its potential role in cancer incidence.
Marina Rayciki Sotomayor, Aline Graciele Henriques Campos, Altair Rodrigues Pires de Paula Filho, Ana Carolina Aredes Goulart, Beatriz Geovana Leite Vacario, Julia Fernandes Gois Orrutéa, Juliana Maria Bitencourt de Morais Valentim, Tatiane Renata Fagundes, Shaiane Carla Gaboardi, Carolina Panis   +9 more
doaj   +1 more source