Results 131 to 140 of about 118,787 (307)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Participation of host cell proteins in inclusion bodies of non-segmented RNA virus infected cells: a molecular insight

Virology Journal
Negative-sense RNA viruses (NSVs) carrying a non-segmented genome encompass a broad group of viruses responsible for numerous human diseases such as rabies, mumps, measles, respiratory illness and encephalitis.
Sharmistha Sarkar, Kriti Kestur Biligiri, Nisha Vats, Shravanti Rampalli, Surajit Ganguly, Naveen Kumar, Debi Prasad Sarkar, Nirmal Kumar Ganguly, Nishi Raj Sharma   +8 more
doaj   +1 more source

Effects of common image manipulations on diagnostic performance in digital pathology: human study [PDF]

, 2013
A very recent work of Ref.[1] studied the effects of image manipulation and image degradation on the perceived attributes of image quality (IQ) of digital pathology slides.
Kumcu, Asli, Marchessoux, Cedric, Philips, Wilfried, Platisa, Ljiljana, Van Brantegem, Leen, Vansteenkiste, Ewout   +5 more
core  

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Molluscum Contagiosum Complicated With an Epidermal Cyst: A Case Report

Clinical Case Reports
Molluscum contagiosum (MC) is a viral infection that primarily affects pediatric patients, sexually active young adults, and immunocompromised individuals of all ages.
Ruixian Niu, Wenjin Geng, Yun Zou, Weian Kuang, Jiangtao Zheng, Xunguo Yin, Na Qiao   +6 more
doaj   +1 more source

PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment

Virologica Sinica
Inclusion bodies (IBs) of respiratory syncytial virus (RSV) are formed by liquid-liquid phase separation (LLPS) and contain internal structures termed "IB-associated granules" (IBAGs), where anti-termination factor M2-1 and viral mRNAs are concentrated. However, the mechanism of IBAG formation and the physiological function of IBAGs are unclear.
Qiang Zhang, Hanzhe Ye, Cong Liu, Haiwu Zhou, Mingbin He, Xiaodong Liang, Yu Zhou, Kun Wang, Yali Qin, Zhifei Li, Mingzhou Chen   +10 more
openaire   +2 more sources

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Coordination of oxysterol binding protein 1 and VAP-A/B modulates the generation of cholesterol and viral inclusion bodies to promote grass carp reovirus replication

Frontiers in Immunology
Similar to other RNA viruses, grass carp reovirus, the causative agent of the hemorrhagic disease, replicates in cytoplasmic viral inclusion bodies (VIBs), orchestrated by host proteins and lipids.
Jia Qi Li, Jia Qi Li, Jie Zhang, Jie Zhang, Yang Chen, Yang Chen, Tao Le, Ming Xian Chang, Ming Xian Chang   +8 more
doaj   +1 more source

Engineering a Sonotherapeutic RBC Membrane‐Derived Nanoparticle Platform for the Treatment of Liver Cancer

Advanced Functional Materials, EarlyView.
Herein, an RBC membrane‐derived nanoparticle (CMN‐ICG) is engineered to efficiently deliver a sonosensitizing agent, indocyanine green (ICG), for sonotherapy of hepatocellular carcinoma (HCC). CMN‐ICG exhibits excellent cytocompatibility, significantly enhances hepatocyte uptake, and produces excessive reactive oxygen species (ROS) upon ultrasound ...
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Juhi Bora, John Joseph Kelly, John Andrew Ronald, Arghya Paul   +6 more
wiley   +1 more source

CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp

Water Biology and Security
Few studies have reported obtaining grass carp resistant to hemorrhagic disease via gene editing in commercial fish. Here, we demonstrate that the expression and activity of grass carp PI4KB (gcPI4KB) are vital for GCRV-I and GCRV-II replication.
Jie Zhang, Liqiang Zhang, Xiaoman Wu, Minhui Tao, Yang Chen, Mingxian Chang   +5 more
doaj   +1 more source