Results 131 to 140 of about 208,695 (255)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Catalytically active inclusion bodies of cold-adapted lipase: production and its industrial potential. [PDF]

AMB Express
Bello MN, Sabri S, Yahaya NM, Shariff FM, Mohamad Ali MS.   +4 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Grass carp reovirus VP35 hijacks DHX15 into phase-separated inclusion bodies to evade host antiviral immunity. [PDF]

Cell Commun Signal
Zhang C, Lv Z, Zeng W, Zhang YA, Tu J.
europepmc   +1 more source

Recombinant human TIM-3 ectodomain expressed in bacteria and recovered from inclusion bodies as a stable and active molecule. [PDF]

Front Bioeng Biotechnol, 2023
Lima GC, Chura-Chambi RM, Morganti L, Silva VJ, Cabral-Piccin MP, Rocha V, Medina TS, Ramos RN, Luz D.   +8 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Expression, Solubilization, and Refolding Recovery of a Novel l‑Asparaginase-Arginase 1 Chimera from <i>E. coli</i> Inclusion Bodies. [PDF]

ACS Omega
Rivera MV, Gabriel Fontes M, Roldán WH, da Silva Junior RCV, Herrera Belén L, Beltrán JF, Lopes-Silva I, Pessoa A, Stephano MA, Farias JG, Costa-Silva TA, Monteiro G.   +11 more
europepmc   +1 more source

Imaging analysis reveals budding of filamentous human metapneumovirus virions and direct transfer of inclusion bodies through intercellular extensions. [PDF]

mBio, 2023
El Najjar F, Castillo SR, Moncman CL, Wu C-Y, Isla E, Velez Ortega AC, Frolenkov GI, Cifuentes-Munoz N, Dutch RE.   +8 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Immobilized inclusion bodies of recombinant cold-adaptive lipase from Antarctic Pseudomonas sp. as catalysts. [PDF]

Appl Microbiol Biotechnol
Bello MN, Sabri S, Yahaya NM, Shariff FM, Ali MSM.   +4 more
europepmc   +1 more source