Results 111 to 120 of about 222,372 (293)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Idiopathic intranuclear inclusion bodies in the renal epithelium of macropods
, 1997 [Extract] Intranuclear inclusion bodies in the renal epithelium of domestic animals are usually caused by heavy metal toxicosis or viruses. Intranuclear inclusions of unknown aetiology and apparently of no clinical significance have been reported in the ...
Skerratt, L.F. +5 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Effect of temperature on protein quality in bacterial inclusion bodies
, 2006 Increasing evidence indicates that protein aggregation in bacteria does not necessarily imply loss of biological activity. Here, we have investigated the effect of growth-temperature on both the activity and stability of the inclusion bodies formed by a ...
Salvador Ventura +3 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
MACHINE LEARNING FOR SMALL BODIES IN THE SOLAR SYSTEM
Machine Learning for Small Bodies in the Solar System provides the latest developments and methods in applications of Machine Learning (ML) and Artificial Intelligence (AI) to different aspects of Solar System bodies, including dynamics, physical ...
Smirnov, Evgeny +2 more
core +1 more source
Neuronal loss and inclusion bodies assessed by histology.
, 2018 There was no observable neurodegeneration (loss of neurons = green stained cells; neurons labelled with anti-NeuN antibody) in the striatum of R6/2 mice by 12 weeks of age (A).
Peter Wipf (134666) +5 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source