Results 221 to 230 of about 7,754,441 (252)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Aerosol of Enoximone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex, Biopharmaceutical Evidence for ARDS Applicability. [PDF]

Pharmaceutics
Migone C, Grassiri B, Vizzoni L, Fabiano A, Ferro B, Zambito Y, Piras AM.   +6 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Structure of Ni(II) Inclusion Complex in Solid/Solution States and the Enhancement of Catalytic Behavior in Electrochemical Hydrogen Production. [PDF]

Molecules
Hamaguchi T, Iseki Y, Ishikawa R, Mishima A, Kawata S.   +4 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Electrochemical Controlling of Double Microgel Layer Formation on an Electrode Surface via an Electrosensitive Inclusion Complex. [PDF]

ACS Mater Au
Marcisz K, Gharakhloo M, Jagleniec D, Pawlowski J, Romanski J, Karbarz M.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Preparation of Eugenol-Thymol-Cuminal Composite Essential Oil Microcapsules with AITC & β-Cyclodextrin Inclusion Complex and Its Effect on Quality of Chilled Pork. [PDF]

Foods
Li W, Yang F, Chen L, Ding K, Chen X.
europepmc   +1 more source

Study of Host-Guest Interaction and In Vitro Neuroprotective Potential of Cinnamic Acid/Randomly Methylated β-Cyclodextrin Inclusion Complex. [PDF]

Int J Mol Sci
De Gaetano F, Leggio L, Celesti C, Genovese F, Falcone M, Giofrè SV, Iraci N, Iraci N, Ventura CA.   +8 more
europepmc   +1 more source

Safety evaluation of a novel effervescent curcumin-ascorbic acid-polysaccharide-β-cyclodextrin inclusion complex: Acute oral toxicity - fixed dose procedure (OECD TG 420) in mice. [PDF]

Toxicol Rep
Wanta A, Aluksanasuwan S, Charoensup R, Jaidee W, Pramvichai C, Saengnoy K, Pongpakit D, Jindarak S, Khamchan A, Ariyawan W, Praserthsee W, Morchang A, Rongjumnong A, Somsuan K.   +13 more
europepmc   +1 more source