Results 51 to 60 of about 3,117,048 (238)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Stable determination of an inclusion by boundary measurements

, 2004
We deal with the problem of determining an inclusion within an electrical conductor from electrical boundary measurements.
Alessandrini, Giovanni, Di Cristo, Michele   +1 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dual virtual element method in presence of an inclusion

, 2017
We consider a Darcy problem for saturated porous media written in dual formulation in presence of a fully immersed inclusion. The lowest order virtual element method is employ to derive the discrete approximation.
Fumagalli, Alessio
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Weak and Strong Convergence Theorems for the Inclusion Problem and the Fixed-Point Problem of Nonexpansive Mappings

Mathematics, 2019
In this work, we study the inclusion problem of the sum of two monotone operators and the fixed-point problem of nonexpansive mappings in Hilbert spaces. We prove the weak and strong convergence theorems under some weakened conditions.
Prasit Cholamjiak, Suparat Kesornprom, Nattawut Pholasa   +2 more
doaj   +1 more source

Greater Social Interest Between Autistic and Non-autistic Conversation Partners Following Autism Acceptance Training for Non-autistic People

Frontiers in Psychology, 2021
Bi-directional differences in social communication and behavior can contribute to poor interactions between autistic and non-autistic (NA) people, which in turn may reduce social opportunities for autistic adults and contribute to poor outcomes ...
Desiree R. Jones, Kerrianne E. Morrison, Kilee M. DeBrabander, Robert A. Ackerman, Amy E. Pinkham, Noah J. Sasson   +5 more
doaj   +1 more source

On the Enumeration of Minimal Dominating Sets and Related Notions

, 2014
A dominating set $D$ in a graph is a subset of its vertex set such that each vertex is either in $D$ or has a neighbour in $D$. In this paper, we are interested in the enumeration of (inclusion-wise) minimal dominating sets in graphs, called the Dom-Enum
Kanté, Mamadou Moustapha, Limouzy, Vincent, Mary, Arnaud, Nourine, Lhouari   +3 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Prediction of effective mechanical properties of composite materials using homogenization approach: Application to tungsten fiber reinforced bulk metallic glass matrix composite

European Mechanical Science, 2018
In this paper, the homogenization approach waspresented to predict the effective mechanical properties of heterogeneous materials such as compositematerials.
Soufiane Belhouideg
doaj   +1 more source