Results 61 to 70 of about 3,117,048 (238)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Some remarks on a fractional differential inclusion with non-separated boundary conditions

Electronic Journal of Qualitative Theory of Differential Equations, 2011
We study a boundary value problem for a fractional differential inclusion of order $\alpha \in (1,2]$ with with non-separated boundary conditions involving a nonconvex set-valued map.
Aurelian Cernea
doaj   +1 more source

New Approaches to Target Mass Corrections

, 2011
We analyze different prescriptions for the inclusion of target mass effects in the extraction of parton distributions from the measured structure functions. As a main result, the problem of defining parton distributions in the presence of mass is an open
Steffens, F. M.
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Beyond inclusion: are clinical trials solving the right problem?

Trials
In 2024, Denmark led the European Union in clinical trials per capita. This is celebrated as a marker of innovation, signalling Denmark’s research capacity and attractiveness to the global industry.
Ulrik Bak Kirk, Nikoletta Georgiou, Ron Hillel, Paloma Moraga   +3 more
doaj   +1 more source

Nonlinear ordered variational inclusion problem involving XOR operation with fuzzy mappings

Journal of Inequalities and Applications, 2020
In the setting of real ordered positive Hilbert spaces, a nonlinear fuzzy ordered variational inclusion problem with its corresponding nonlinear fuzzy ordered resolvent equation problem involving XOR operation has been recommended and solved by employing
Iqbal Ahmad, Syed Shakaib Irfan, Mohammad Farid, Preeti Shukla   +3 more
doaj   +1 more source

Two hybrid and non-hybrid k-dimensional inclusion systems via sequential fractional derivatives

Advances in Difference Equations, 2021
Some complicated events can be modeled by systems of differential equations. On the other hand, inclusion systems can describe complex phenomena having some shocks better than the system of differential equations.
Seher Melike Aydogan, Fethiye Muge Sakar, Mostafa Fatehi, Shahram Rezapour, Hashem Parvaneh Masiha   +4 more
doaj   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

FOURIER PROBLEM FOR WEAKLY NONLINEAR EVOLUTION INCLUSIONS WITH FUNCTIONALS

Journal of Optimization, Differential Equations and Their Applications, 2019
The Fourier problem or, in other words, the problem without initial conditions for evolution equations and inclusions arise in modeling different nonstationary processes in nature, that started a long time ago and initial conditions do not affect on them
Mykola M. Bokalo, Iryna V. Skira
doaj   +1 more source