Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Infrequent Cooperative Breeding in a Short-Lived Migratory Songbird, the Wilson’s Warbler
BirdsCooperative breeding, or helping behavior, has long been recognized in birds. An ignored dichotomy, however, separates the helping found in many individuals of some long-lived, sedentary species from the helping occasionally found in the territories of ...
William Gilbert
doaj +1 more source
No Signs of Inclusive Fitness or Reciprocal Altruism in Advantageous Inequity Aversion. [PDF]
Evol Psychol, 2023 Antfolk J +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
The maps of meaning consciousness theory
Frontiers in PsychologyIn simple terms, consciousness is constituted by multiple goals for action and the continuous adjudication of such goals to implement action, which is referred to as the maps of meaning (MoM) consciousness theory.
Scott Andersen, Scott Andersen
doaj +1 more source
No evidence that religious celibacy confers inclusive fitness benefits: a comment on: 'Studying human culture with small datasets and evolutionary models' Micheletti et al. (2022). [PDF]
Proc Biol Sci, 2023 von Pein LI, Harper KT, Zietsch BP.
europepmc +1 more source
Review of 'John R Searle-Thinking About the Real World' by Franken et al eds. (2010)(review revised 2019) [PDF]
, 2019 This book is the result of Searle's stay in the Munster University Philosophy Dept in 2009 and all the papers except his introductory one and his final response are from persons associated with Munster.
Starks, Michael
core
Checkpoint blockade and the stem‐like T cell trade‐off
Molecular Oncology, EarlyView.Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley +1 more source
Correction to: 'Religious celibacy brings inclusive fitness benefits' (2022) by Micheletti et al. [PDF]
Proc Biol Sci, 2023 Micheletti AJC +5 more
europepmc +1 more source