Results 121 to 130 of about 974,747 (262)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

No evidence that religious celibacy confers inclusive fitness benefits: a comment on: 'Studying human culture with small datasets and evolutionary models' Micheletti et al. (2022). [PDF]

Proc Biol Sci, 2023
von Pein LI, Harper KT, Zietsch BP.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Genetic Relatedness Promotes Equal Contributions of Males and Females to Brood Care in a Biparental Cichlid Fish

Ecology and Evolution
Kin discrimination, that is, the differential treatment of kin and nonkin has been studied in a wide range of social contexts because kin selection theory predicts that genetic relatedness among interacting individuals can reduce conflicts and promote ...
Timo Thünken, Janosch Diederich, Simon Vitt, Ranê Aytaç   +3 more
doaj   +1 more source

Correction to: 'Religious celibacy brings inclusive fitness benefits' (2022) by Micheletti et al. [PDF]

Proc Biol Sci, 2023
Micheletti AJC, Ge E, Zhou L, Chen Y, Du J, Mace R.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effects of 8-week of fitness classes on blood pressure, body composition, and physical fitness

, 2020
BACKGROUND: Fitness activities such as indoor cycling (IC), Zumba® (ZU) and body pump (BP) are practiced by large segments of population. There are no studies showing which kind of fitness activity can produce more health benefits.
Carlos-Vivas, Jorge, Pérez-Gómez, Jorge, Chavarrias, Manuel, Barrantes-Martín, Beatriz   +3 more
core   +1 more source

Religious celibacy brings inclusive fitness benefits. [PDF]

Proc Biol Sci, 2022
Micheletti AJC, Ge E, Zhou L, Chen Y, Zhang H, Du J, Mace R.   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Lack of intergenerational reproductive conflict, rather than lack of inclusive fitness benefits, explains absence of post-reproductive lifespan in long-finned pilot whales. [PDF]

Behav Ecol, 2023
McCormack JL, Arbuckle K, Fullard K, Amos W, Nichols HJ.   +4 more
europepmc   +1 more source