Results 101 to 110 of about 19,806 (267)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Digital Fitness and Sustainable Consumption: Understanding Consumer Motivations and Barriers [PDF]
European Journal of Interdisciplinary StudiesAs digital fitness platforms and wellness technologies become the norm in modern health routines, understanding what impacts the user's engagement is key to creating inclusive, ethical and sustainable solutions.
Maria BRIANA, Ioannis KOSTAKIS
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Phyllomedusa: Journal of Herpetology, 2008 According to inclusive fitness theory, cooperation between related individuals should ameliorate the effect of intraspecific competition. However, close relatedness is also thought to increase similarity between individuals and therefore increase the ...
Evan Twomey +2 more
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Inclusive fitness explains behavioral diversity in a social bird. [PDF]
Proc Natl Acad Sci U S A, 2023 Riehl C, LaPergola JB.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Infrequent Cooperative Breeding in a Short-Lived Migratory Songbird, the Wilson’s Warbler
BirdsCooperative breeding, or helping behavior, has long been recognized in birds. An ignored dichotomy, however, separates the helping found in many individuals of some long-lived, sedentary species from the helping occasionally found in the territories of ...
William Gilbert
doaj +1 more source
MATHEMATICS EDUCATION: STRATEGIES OF FITNESS FOR INCLUSIVE EDUCATION [PDF]
Revista Gestão & Saúde, 2013 This research addresses the need and possibilities of adopting inclusive practices in school, today, as well as understanding what has been posted. Know to today that the school enrollment has been much discussion in the scientific community and we need ...
José Eduardo de Oliveira Evangelista Lanuti +1 more
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