Results 81 to 90 of about 974,747 (262)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Fitness, inclusive fitness, and optimization [PDF]
, 2019 Individual-as-maximizing agent analogies result in a simple understanding of the functioning of the biological world. Identifying the conditions under which individuals can be regarded as fitness maximizing agents is thus of considerable interest to ...
Lehmann, Laurent, Rousset, François
core
Ecology and Evolution, 2019 A multitude of factors may determine reproductive skew among cooperative breeders. One explanation, derived from inclusive fitness theory, is that groups can partition reproduction such that subordinates do at least as well as noncooperative solitary ...
Peter Nonacs
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Generalisations of Hamilton's Rule Applied to Non-Additive Public Goods Games with Random Group Size
Frontiers in Ecology and Evolution, 2014 Inclusive fitness theory has been described as being limited to certain special cases of social evolution. In particular some authors argue that the theory can only be applied to social interactions having additive fitness effects, and involving only ...
James A R Marshall
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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Frontiers in Robotics and AIIntroductionAutonomous agents increasingly interact within social domains such as customer service, transportation, and healthcare, often acting collectively on behalf of humans.
Jory Schossau +3 more
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Fitness Estimation for Ecological Studies: An Evaluation in Columbian Ground Squirrels
Frontiers in Ecology and Evolution, 2020 The topics of evolution by natural selection and ecological interactions are closely intertwined. Thus, measurements of evolutionary fitness are ubiquitous in the ecological literature. As an empirical problem, the components of fitness, reproduction and
F. Stephen Dobson +3 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
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