Results 81 to 90 of about 19,806 (267)

Generalisations of Hamilton's Rule Applied to Non-Additive Public Goods Games with Random Group Size

Frontiers in Ecology and Evolution, 2014
Inclusive fitness theory has been described as being limited to certain special cases of social evolution. In particular some authors argue that the theory can only be applied to social interactions having additive fitness effects, and involving only ...
James A R Marshall
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Fitness Estimation for Ecological Studies: An Evaluation in Columbian Ground Squirrels

Frontiers in Ecology and Evolution, 2020
The topics of evolution by natural selection and ecological interactions are closely intertwined. Thus, measurements of evolutionary fitness are ubiquitous in the ecological literature. As an empirical problem, the components of fitness, reproduction and
F. Stephen Dobson, F. Stephen Dobson, Jan O. Murie, Vincent A. Viblanc   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Incentivising cooperation by judging a group’s performance by its weakest member in neuroevolution and reinforcement learning

Frontiers in Robotics and AI
IntroductionAutonomous agents increasingly interact within social domains such as customer service, transportation, and healthcare, often acting collectively on behalf of humans.
Jory Schossau, Bamshad Shirmohammadi, Arend Hintze, Arend Hintze   +3 more
doaj   +1 more source

Self-sacrifice in 'desperado' contests between relatives

Frontiers in Zoology, 2010
Intra-specific competition occurs in all animal species and can lead to escalated conflict. Overt fighting entails the risk of injury or death, and is usually avoided through the use of conventions or pre-fight assessments. However, overt fighting can be
Monnin Thibaud, Cronin Adam L
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

What is inclusive fitness theory, and what is it for? [PDF]

, 2016
Inclusive fitness theory is a cornerstone of modern evolutionary biology, yet critics contend it is not general but subject to serious limitations, and is ripe for replacement, for example by multilevel selection theory.
Marshall, J.A.R.
core   +1 more source