Results 91 to 100 of about 154,113 (272)

Queen control of a key life-history event in a eusocial insect [PDF]

, 2013
In eusocial insects, inclusive fitness theory predicts potential queen–worker conflict over the timing of events in colony life history. Whether queens or workers control the timing of these events is poorly understood.
Andrew F. G. Bourke, Aron S, Florian S. Guidat, Jacob G. Holland, Maynard Smith J, Oster GF   +5 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Reproductive skew in cooperative breeding: Environmental variability, antagonistic selection, choice, and control

Ecology and Evolution, 2019
A multitude of factors may determine reproductive skew among cooperative breeders. One explanation, derived from inclusive fitness theory, is that groups can partition reproduction such that subordinates do at least as well as noncooperative solitary ...
Peter Nonacs
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Fitness Estimation for Ecological Studies: An Evaluation in Columbian Ground Squirrels

Frontiers in Ecology and Evolution, 2020
The topics of evolution by natural selection and ecological interactions are closely intertwined. Thus, measurements of evolutionary fitness are ubiquitous in the ecological literature. As an empirical problem, the components of fitness, reproduction and
F. Stephen Dobson, F. Stephen Dobson, Jan O. Murie, Vincent A. Viblanc   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Function attribution depends on the explanatory context: A Reply to Neander and Rosenberg's Reply to Nanay [PDF]

, 2012
In ‘A modal theory of function’, I gave an argument against all existing theories of function and outlined a new theory. Karen Neander and Alex Rosenberg argue against both my negative and my positive claim.
Nanay, Bence
core  

Inclusive Fitness 101: Math Not Required [PDF]

Trends in Ecology & Evolution, 2016
Inclusive fitness theory delivers a clever solution to the problem of altruism, especially the case of sterile worker castes in social insects. The idea behind the inclusive fitness theory is straight forward and contemporary: if you can somehow outsource reproduction, then you may reduce (or stop) personal reproduction.
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Incentivising cooperation by judging a group’s performance by its weakest member in neuroevolution and reinforcement learning

Frontiers in Robotics and AI
IntroductionAutonomous agents increasingly interact within social domains such as customer service, transportation, and healthcare, often acting collectively on behalf of humans.
Jory Schossau, Bamshad Shirmohammadi, Arend Hintze, Arend Hintze   +3 more
doaj   +1 more source