Results 111 to 120 of about 154,113 (272)

ICARUS: Intelligent coupon allocation for retailers using search [PDF]

open access: yes, 2005
Many retailers run loyalty card schemes for their customers offering incentives in the form of money off coupons. The total value of the coupons depends on how much the customer has spent.
Crampton, J, Shi, A, Swift, S, Tucker, A
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Digital Fitness and Sustainable Consumption: Understanding Consumer Motivations and Barriers [PDF]

open access: yesEuropean Journal of Interdisciplinary Studies
As digital fitness platforms and wellness technologies become the norm in modern health routines, understanding what impacts the user's engagement is key to creating inclusive, ethical and sustainable solutions.
Maria BRIANA, Ioannis KOSTAKIS
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Inclusive fitness explains behavioral diversity in a social bird. [PDF]

open access: yesProc Natl Acad Sci U S A, 2023
Riehl C, LaPergola JB.
europepmc   +1 more source

Inclusive fitness: 50 years on. [PDF]

open access: yesPhilos Trans R Soc Lond B Biol Sci, 2014
Gardner A, West SA.
europepmc   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The effect of kinship on intraspecific competition in larvae of the poison frog Ameerega bassleri (Anura, Dendrobatidae)

open access: yesPhyllomedusa: Journal of Herpetology, 2008
According to inclusive fitness theory, cooperation between related individuals should ameliorate the effect of intraspecific competition. However, close relatedness is also thought to increase similarity between individuals and therefore increase the ...
Evan Twomey   +2 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

MATHEMATICS EDUCATION: STRATEGIES OF FITNESS FOR INCLUSIVE EDUCATION [PDF]

open access: yesRevista Gestão & Saúde, 2013
This research addresses the need and possibilities of adopting inclusive practices in school, today, as well as understanding what has been posted. Know to today that the school enrollment has been much discussion in the scientific community and we need ...
José Eduardo de Oliveira Evangelista Lanuti   +1 more
doaj  

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