Results 61 to 70 of about 115,467 (307)

Assessment of the learning curve of peribulbar blocks using the Learning-Curve Cumulative Sum Method (LC-CUSUM): an observational study

Brazilian Journal of Anesthesiology
Introduction: This study aimed to assess the learning curves of peribulbar anesthesia and estimate the number of blocks needed to attain proficiency. Methods: Anonymized records of sequential peribulbar blocks performed by first-year anesthesia residents
Getúlio Rodrigues de Oliveira Filho, Victor Medeiros Benincá   +1 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Characteristics for Distinguishing Among Balanced Incomplete Block Designs with Repeated Blocks [PDF]

, 1985
20 pages, 1 article*Characteristics for Distinguishing Among Balanced Incomplete Block Designs with Repeated Blocks* (Raghavarao, W. T.; Federer, W. T.; Seiden, E.; Schwager, S.
Seiden, E., Schwager, S. J., Cornell University. Dept. of Biological Statistics and Computational Biology., Cornell University. Biometrics Unit., Raghavarao, W. T., Cornell University. Dept. of Biometrics., Federer, W. T.   +6 more
core  

Partial Diallel Crosses in Incomplete Blocks

, 2021
Various forms of diallel crosses play an important role in evaluating the breeding potential of genetic material in plant and animal breeding (e.g., Hinkelmann, 1975, in A Survey of Statistical Design and Linear Models, 243-269. Amsterdam: North Holland).
Singh, Murari
core  

Convex Cone Conditions on the Structure of Designs [PDF]

, 2003
Various known and original inequalities concerning the structure of combinatorial designs are established using polyhedral cones generated by incidence matrices. This work begins by giving definitions and elementary facts concerning t-designs.
Dukes, Peter James
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Missing Data Imputation in Balanced Construction for Incomplete Block Designs

Mathematics
Observational data with massive sample sizes are often distributed on many local machines. From an experimental design perspective, investigators often desire to identify the effect of new treatments (even ML algorithms) on many blocks of experimental ...
Haiyan Yu, Bing Han, Nicholas Rios, Jianbin Chen   +3 more
doaj   +1 more source

A Multi-Agent Proposal for the Resolution of BIBD Instances

Revista Colombiana de Estadística, 2016
The problem with designing balanced incomplete blocks (BIBD) is enclosed within the combinatorial optimization approach that has been extensively used in experimental design.
DAVID RODRÍGUEZ, ENRIQUE DARGHAN, JULIO MONROY   +2 more
doaj   +1 more source