Results 81 to 90 of about 2,352,461 (298)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Black Box Optimization for Ergodic Systems in Markov Chains

open access: yesMathematics
This paper studies a black-box methodology for optimizing ergodic stochastic systems, focusing on the construction of scalar measures that reliably indicate progress toward optimality. Our starting point is a state-value quantity that inherently exhibits
Julio B. Clempner
doaj   +1 more source

INFORMATION PROCESSING WITH AN OPTICAL SENSOR WHEN INCOMPLETE INITIAL INFORMATION

open access: yesAdaptivni Sistemi Avtomatičnogo Upravlinnâ, 2019
The range of tasks, solved by the properties of classification and generalization, is quite broad. However, the quality of solving to the problem, for one reason or another, is not always the same.
Igor Parkhomey   +3 more
doaj   +1 more source

Markov games with frequent actions and incomplete information

open access: yes, 2013
We study a two-player, zero-sum, stochastic game with incomplete information on one side in which the players are allowed to play more and more frequently.
Cardaliaguet, Pierre   +3 more
core   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

The F\"ollmer-Schweizer decomposition under incomplete information

open access: yes, 2016
In this paper we study the F\"ollmer-Schweizer decomposition of a square integrable random variable $\xi$ with respect to a given semimartingale $S$ under restricted information.
Ceci, Claudia   +2 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Mediation: Incomplete information bargaining with [PDF]

open access: yes
We analyze a continuous-time bilateral double auction in the presence of two-sided incomplete information and a smallest money unit. A distinguishing feature of our model is that intermediate concessions are not observable by the adversary: they are only
Clara Ponsat?Author-Name: Jozsef Sakovics   +1 more
core  

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