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GLUCOREGULATORY ACTIONS OF INCRETINS/ANTI-INCRETINS
Diabetes mellitus (DM) is a chronic debilitating and non-communicable disease characterized by chronic hyperglycemia and resulting from a defect in insulin secretion, insulin action, or both. Apart from these, defective actions of the gastrointestinal (GI) incretin hormones: glucagon-like peptide–1 (GLP-1) and glucose-dependent insulinotropic ...openaire +1 more source
2010
WNT signaling is emerging as a global regulator of metabolism, targeting multiple tissues. This is achieved either directly through Wnt receptors, or indirectly through the action of incretins, hormones that enhance glucose-stimulated insulin secretion and target extrapancreatic organs that cooperatively control whole body energy balance. WNT increases
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WNT signaling is emerging as a global regulator of metabolism, targeting multiple tissues. This is achieved either directly through Wnt receptors, or indirectly through the action of incretins, hormones that enhance glucose-stimulated insulin secretion and target extrapancreatic organs that cooperatively control whole body energy balance. WNT increases
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Incretin enhancers, incretin mimetics – from therapeutic concept to clinical application
Orvosi Hetilap, 2007Inkretineknek az emésztőtraktus speciális sejtjeiben termelődő, peptid természetű hormonokat nevezzük, amelyek a táplálék összetevői, elsősorban szénhidrátkomponensei hatására elválasztódva, közvetett módon, összetett hatásmechanizmussal – döntően a postprandialis vércukorszint csökkentésével – részt vesznek a glükózhomeosztázis biztosításában.
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1988
Publisher Summary This chapter provides an overview of incretin. According to LaBarre, incretin refers to endocrine factors from the gut with insulinotropic activity. An incretin should fulfill these conditions: (1) it must be released by nutrients, especially carbohydrates, (2) it must stimulate insulin secretion in the presence of elevated blood ...
W. Creutzfeldt, R. Ebert
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Publisher Summary This chapter provides an overview of incretin. According to LaBarre, incretin refers to endocrine factors from the gut with insulinotropic activity. An incretin should fulfill these conditions: (1) it must be released by nutrients, especially carbohydrates, (2) it must stimulate insulin secretion in the presence of elevated blood ...
W. Creutzfeldt, R. Ebert
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Vnitrni lekarstvi, 2011
Incretin hormones are peptides that are secreted from endocrine cell of gastrointestinal tract after nutrient ingestion and stimulate insulin secretion. Glucosodependent Insulinotropic Peptide--GIP is released from K-cells of duodenum and proximal jejunum, recently GIP synthesis has been proved in pancreatic alpha cells.
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Incretin hormones are peptides that are secreted from endocrine cell of gastrointestinal tract after nutrient ingestion and stimulate insulin secretion. Glucosodependent Insulinotropic Peptide--GIP is released from K-cells of duodenum and proximal jejunum, recently GIP synthesis has been proved in pancreatic alpha cells.
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[Incretin enhancer: sitagliptin].
Nihon rinsho. Japanese journal of clinical medicine, 2011Recently, incretin-based therapies have become available for patients with type 2 diabetes in Japan. Sitagliptin is one of several DPP-4 inhibitors. After an OGTT, active endogenous GLP-1 concentrations are increased about twofold by sitagliptin. In clinical trials, sitagliptin was shown to be effective in monotherapy and in combination with other oral
Manabu, Kondo, Yukio, Tanizawa
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RD Lawrence Lecture 2017 Incretins: the intelligent hormones in diabetes
Diabetic Medicine, 2018V. Gault
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Intestinal Incretins and the Regulation of Bone Physiology.
Advances in Experimental Medicine and Biology, 2017Walter Ramsey, C. Isales
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