Results 121 to 130 of about 2,629,038 (335)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

New horizons of microphysiological systems: India forging its path in human-relevant research

open access: yesBiology Open, 2023
Surat Parvatam   +5 more
doaj   +1 more source

Estimation and prediction method of lithium battery state of health based on ridge regression and gated recurrent unit

open access: yesIET Energy Systems Integration
The health state of lithium‐ion batteries is influenced by the operating conditions of energy storage stations and battery characteristics. It is challenging to obtain real‐time characterisation parameters like maximum discharge capacity and internal ...
Ziwei Dai   +6 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Spontaneous granulation of tricaprin and trilaurin medium-chain triacylglycerols with added medium- and long-chain species

open access: yesnpj Science of Food
To utilize medium-chain triacylglycerol (MCT) with a low smoke point (~150 °C) in water, we investigated formulations and physical conditions for its spontaneous powdery crystallization without excipients. Crystallization of tricaprin and trilaurin mixed
Yutaro Kataoka   +2 more
doaj   +1 more source

Epistemology of Business Incubators and the Incubation theory

open access: yesInternational Journal of Entrepreneurship and Small Business, 2020
Balvinder Shukla, A. Sharma, Manoj Joshi
openaire   +2 more sources

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