Results 81 to 90 of about 2,651,058 (301)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A machine learning model that outperforms conventional global subseasonal forecast models
Nature CommunicationsSkillful subseasonal forecasts are crucial for various sectors of society but pose a grand scientific challenge. Recently, machine learning-based weather forecasting models outperform the most successful numerical weather predictions generated by the ...
Lei Chen +11 more
doaj +1 more source
The role and the contribution of business incubators in supporting economic developments [PDF]
, 2010 This paper reports, explores and investigates on the initiatives whereby incubators were used to stimulate the economy. Initially the study pursued the role of business incubator organisations and their impacts on the economic developments in the ...
Al-Karaghouli, W, Busler, M
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
BMC MicrobiologyBackground Pear black spot is caused by Alternaria tenuissima. It is one of the diseases of concern limiting pear production worldwide. Existing cultivation methods and fungicides are not sufficient to control early blight.
Yi-Huang Chen +6 more
doaj +1 more source
The effect of static incubation on the yolk sac vasculature of the Japanese quail (Coturnix c. japonica) [PDF]
, 2006 Static incubation affects early embryonic development with, notably, a reduction area vasculosa expansion and diminished sub-embryonic fluid (SEF) volume, effects produced during a ‘critical’ period (3-7 days in the chick) (Baggott et al., 2002).
Baggott, Glenn K., Shapland, F
core
Confocal Raman data analysis enables identifying apoptosis of MCF-7 cells caused by anticancer drug paclitaxel [PDF]
, 2013 Confocal Raman microscopy is a noninvasive, label-free imaging technique used to study apoptosis of live MCF-7 cells. The images are based on Raman spectra of cells components, and their apoptosis is monitored through diffusion of cytochrome c in ...
Attila-Gergely Vegh +7 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effects of Incubation and Rearing Temperatures on Caiman latirostris Growth [PDF]
, 2010 Different studies found that incubation temperature has an influence on the size of Caiman latirostris hatchlings and determines their gonadal sex. Experimental manipulations revealed that the effects of temperature on growth are independent of sex ...
Larriera, Alejandro +3 more
core
, 2008 Homogeneous nucleation and growth in a simplest two-dimensional phase field model is numerically studied using the cell dynamics method. Whole process from nucleation to growth is simulated and is shown to follow closely the Kolmogorov-Johnson-Mehl ...
Christian J. W. +6 more
core +1 more source