Results 61 to 70 of about 2,651,058 (301)

Amentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome

Frontiers in Pharmacology, 2019
Brain inflammation is one of the main causes of epileptogenesis, a chronic process triggered by various insults, including genetic or acquired factors that enhance susceptibility to seizures. Amentoflavone, a naturally occurring biflavonoid compound that
Shikuo Rong, Ding Wan, Ding Wan, Yayun Fan, Shenhai Liu, Kuisheng Sun, Junming Huo, Peng Zhang, Xinxiao Li, Xiaoliang Xie, Feng Wang, Feng Wang, Tao Sun, Tao Sun   +13 more
doaj   +1 more source

Flavanol monomer-induced changes to the human faecal microflora [PDF]

, 2008
We have investigated the bacterial-dependent metabolism of ( − )-epicatechin and (+)-catechin using a pH-controlled, stirred, batch-culture fermentation system reflective of the distal region of the human large intestine.
Xenofon Tzounis, Jelena Vulevic, Gunter G. C. Kuhnle, Trevor George, Jadwiga Leonczak, Glenn R. Gibson, Catherine Kwik-Uribe, Jeremy P. E. Spencer, Wilson, Frayn, Gibson, Hughes, Garsetti, Matsui   +13 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Ovicidal Activity of 2-Hydroxy-4-Methoxybenzaldehyde, Derivatives and Structural Analogues on Anopheles gambiae Eggs

Journal of Chemistry
Effective remedies for disrupting An. gambiae metamorphosis at the egg stage are crucial in suppression of the malaria vector populations that result in the reduction of disease burden.
Reu E. Andati, Maurice O. Omolo, Isaiah O. Ndiege   +2 more
doaj   +1 more source

Directed percolation with incubation times

, 2006
We introduce a model for directed percolation with a long-range temporal diffusion, while the spatial diffusion is kept short ranged. In an interpretation of directed percolation as an epidemic process, this non-Markovian modification can be understood ...
Andrea Jiménez-Dalmaroni, D. Mollison, J. Adamek, P. Grassberger, S. M. Dammer   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An Analysis of a Harmonization of Homo Ludens and Homo Faber for Academics as a Recommendation for Incubation Facility Design in a Staffs Room [PDF]

, 2019
Humans work to meet their basic needs for living. In anthropology, there is a term Homo Faber, which means that humans work and refers to the human ability to control their destiny and what surrounds them.
Graniadi, M. F. (Muhammad ), Yudiarti, D. (Diena)   +1 more
core  

Innate immunity, assessed by plasma NO measurements, is not suppressed during the incubation fast in eiders [PDF]

, 2006
Immunity is hypothesized to share limited resources with other physiological functions and may mediate life history trade-offs, for example between reproduction and survival.
Adamo, Archer, Berczi, Bourgeon, Bourgeon, Crippen, Criscuolo, Criscuolo, Daniel Ricquier, Demas, Demas, Demas, Elizalde, Eraud, Faggioni, François Criscuolo, Gross, Gullo, Guzik, Hamilton, Hangalapura, Hangalapura, Hanssen, Hanssen, Hanssen, Hanssen, Harvey, Hickman-Miller, Jarosinski, Keil, Korschgen, Lillehoj, Lord, Lourenco, Love, Lõhmus, Lõhmus, MacColl, MacDonald, Martin, Nilsson, Nordling, Norris, Ricart-Jané, Ricklefs, Rodriguez, Roitt, Råberg, Salman, Sheldon, Sophie Bourgeon, Svensson, Szabo, Thierry Raclot, Tieleman, Tosi, Verhulst, Viney, von Schantz, Wiersma, Yoccoz, Yvon Le Maho, Zuk   +62 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Impacts of dietary Saccharomyces cerevisiae fermentation derived postbiotic on growth performance and health status of Pacific white shrimp

Scientific Reports
A 60-day feeding experiment was carried out to assess the impacts of dietary Saccharomyces cerevisiae fermentation-derived postbiotic (SCFP) (DVAQUA) on growth performance, nutrient utilization, whole-body proximate composition, digestive and antioxidant
Elangovan Prabu, Nathan Felix, Victor L. Nsereko, Jarin Sawanboonchun, Arumugam Uma, Govindharaj Sathishkumar, Pushparaj Chidambaram, Thangaraju Thiruvasagam, Krishnan Ravaneswaran   +8 more
doaj   +1 more source