Results 71 to 80 of about 1,716,828 (267)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Composition and Functional Properties of Tender Coconut Water: Effect of Variety and Maturity Stage

Future Postharvest and Food
This study investigated the effects of three coconut varieties—Malayan Yellow Dwarf (MYD), Malayan Orange Dwarf (MOD), and Chowghat Orange Dwarf (COD)—harvested at 6‐, 7‐, and 8‐month maturity on the physicochemical, nutritional, enzymatic, and sensory ...
Raja Vijayakumar, Suruthi Muthusamy, Shubham Nimbkar, Thirukumaran Ramesh, Aditi Negi, Jeyan Arthur Moses, Vadakkepulppara Ramachandran Nair Sinija   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of additives on the synthesis efficiency of nanoparticles by laser-induced reduction

Beilstein Journal of Nanotechnology
Laser-induced reduction in liquid (LRL) is a physicochemical technique for synthesizing nanoparticles by irradiating a solution containing metal ions with a high-intensity laser.
Rikuto Kuroda, Takahiro Nakamura, Hideki Ina, Shuhei Shibata   +3 more
doaj   +1 more source

Synergistic blend: Curcumin-loaded silver nanoparticles synthesized from Talaromyces atroroseus pigment for bio evaluation

Plant Nano Biology
Metallic silver, particularly in the form of silver nanoparticles (AgNPs), has gained renewed attention as a powerful antimicrobial solution. In the present investigation, AgNP was synthesized using pigments produced by Talaromyces atroroseus, and ...
R. Aakash, Kavyarathna, Nagananda G S, Kavya T R, Roopa Reddy, K.U. Minchitha, S. Swetha, Sandeep Suryan   +7 more
doaj   +1 more source

Discriminant canonical analysis as a tool to determine traces of endangered native hen breed introgression through egg hatchability phenomics [PDF]

Animal Bioscience
Objective The main objective of this study was to develop a pipeline to detect phenogenomic introgression across different multivariety breeds and to validate such classification focusing on external egg and hatchability-related traits using a ...
Antonio González Ariza, Francisco Javier Navas González, Ander Arando Arbulu, José Manuel León Jurado, Juan Vicente Delgado Bermejo, María Esperanza Camacho Vallejo   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Suppression of phytopathogenic fungi using garlic, horsetail, and yarrow plant extracts [PDF]

Journal of Central European Agriculture
Organic production is a system of sustainable agriculture based on a high respect for environmental principles through the rational use of natural resources, renewable energy sources, conservation of natural diversity, and environmental protection. Plant
Saud Hamidović, Berina IMAMOVIĆ, Fejzo BAŠIĆ, Muamer BEZDROB, Nermin RAKITA, Blažo LALEVIĆ   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

New horizons of microphysiological systems: India forging its path in human-relevant research

Biology Open, 2023
Surat Parvatam, Kasturi Mahadik, Anushka Banerjee, Kadambari Patil, V. Radha, Madhusudhana Rao   +5 more
doaj   +1 more source