Results 41 to 50 of about 1,835 (185)
Progress Toward Replacing Animals in Toxicity Testing for Cosmetics [PDF]
, 2012 In the 1980’s, animal rights activists successfully motivated the cosmetic industry to begin researching alternatives to animal tests.
Nye, Marisa B.
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Journal of Basic Microbiology, Volume 65, Issue 8, August 2025.ABSTRACT Rhizorhabdus wittichii RW1 is known for its ability to degrade polycyclic aromatic hydrocarbons, such as dibenzo‐p‐dioxin (DD) and dibenzofuran (DF). We hypothesized that the R. wittichii RW1 benzoate 1,2‐dioxygenase shares electron transfer components with the DD/DF angular dioxygenase (DxnA1A2), similar to many aromatic hydrocarbon degrading
Igor Ivanovski +2 more
wiley +1 more source
Journal of the Brazilian Chemical Society, 2006 The rearrangement of beta,gamma-unsaturated esters, such as 2-(3,4-dihydronaphthalen-1-yl)-propionic acid ethyl ester, with thallium trinitrate (TTN) in acetic acid leads to 3-indan-1-yl-2-methyl-3-oxo-propionic acid ethyl ester in good yield, through a ...
Silva Jr. Luiz F. +2 more
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The Journal of Physiology, Volume 603, Issue 15, Page 4255-4291, 1 August 2025.Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich +9 more
wiley +1 more source
Research progress of donepezil for treating mild to moderate Alzheimer's disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2017 Donepezil is the second generation of cholinesterase inhibitors (ChEIs), which has a good effect on mild to moderate Alzheimer's disease (AD). In recent years, there were a lot of studies on the mechanism of donepezil. This paper mainly introduces the
Xin-xin LI, Yun-yun ZHANG, Bin WANG
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ECVAM Technical Report on the Status of Alternative Methods for Cosmetics Testing (2008-2009) [PDF]
, 2010 The ECVAM technical report presents the progress made in the development and validation of alternative methods for the human health effects relevant to the Cosmetics Directive. It provides an update on the activities described by ECVAM in 2005 , 2006 and
BREMER Susanne +12 more
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Chemistry – A European Journal, Volume 31, Issue 42, July 25, 2025.Novel merocyanine derivatives with a strong diphenyl‐dihydrophenazine donor and a series of strong electron acceptors were developed. The indanone and indandione acceptor units were modified by dicyanovinylene groups to tune acceptor strength. Among these derivatives, DPPZ‐IDD realized an ultranarrow electrochemical gap of 0.93 eV and an optical band ...
Kateřina Teichmanová +8 more
wiley +1 more source
Hochgradig enantioselektive Organokatalyse mit zweizähnigen Halogenbrückendonoren
Angewandte Chemie, Volume 137, Issue 30, July 21, 2025.In einer Mukaiyama‐Aldol‐Modellreaktion mit allgemeinen Substraten wurden hohe Enantioselektivitäten mit einem modifizierbaren, bidentaten Iod(I)‐basierten Halogenbrücken‐Organokatalysator erreicht. Die entscheidende Rolle der Halogenbrücken wurde durch das schlechte Abschneiden des entsprechenden Wasserstoffbrückendonors und durch DFT‐Berechnungen ...
Julian Wolf +6 more
wiley +1 more source
Highly Enantioselective Organocatalysis with Bidentate Halogen Bond Donors
Angewandte Chemie International Edition, Volume 64, Issue 30, July 21, 2025.In a model Mukaiyama aldol reaction with unbiased substrates, high enantioselectivity was achieved with a modifiable bidentate iodine(I)‐based halogen bonding organocatalyst. The crucial role of halogen bonding was confirmed by the low performance of the corresponding hydrogen bond donor and via DFT calculations.
Julian Wolf +6 more
wiley +1 more source
Examining the regulatory value of multi-route mammalian acute systemic toxicity studies [PDF]
, 2011 Regulatory information requirements for pesticides call for submission of acute systemic toxicity data for up to three different exposure routes (oral, dermal, inhalation) for both active ingredients and formulated products.
BULGHERONI Anna +2 more
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