Results 21 to 30 of about 97 (91)

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

3‐Dicyanomethylene‐Substituted Thienothiophenes as the Terminal Units in Non‐Fullerene Electron Acceptor Molecules for Organic Photovoltaics

Chemistry – An Asian Journal, Volume 20, Issue 16, August 14, 2025.
3‐Dicyanomethylene thienothiophenes (CNTTs), a new series of electron acceptor units, were developed and incorporated into non‐fullerene acceptors (NFAs). The CNTT‐based NFAs exhibited favorable electronic structures and packing structures and thus enabled organic photovoltaic devices to achieve a power conversion efficiency of 10% when blended with ...
Kensuke Shibahashi, Masato Nakamura, Kohsuke Kawabata, Kazuo Takimiya   +3 more
wiley   +1 more source

Analysis of Benzoate 1,2‐Dioxygenase Identifies Shared Electron Transfer Components With DxnA1A2 in Rhizorhabdus wittichii RW1

Journal of Basic Microbiology, Volume 65, Issue 8, August 2025.
ABSTRACT Rhizorhabdus wittichii RW1 is known for its ability to degrade polycyclic aromatic hydrocarbons, such as dibenzo‐p‐dioxin (DD) and dibenzofuran (DF). We hypothesized that the R. wittichii RW1 benzoate 1,2‐dioxygenase shares electron transfer components with the DD/DF angular dioxygenase (DxnA1A2), similar to many aromatic hydrocarbon degrading
Igor Ivanovski, Suha Eleya, Gerben J. Zylstra   +2 more
wiley   +1 more source

Rearrangement of beta,gamma-unsaturated esters with thallium trinitrate: synthesis of indans bearing a beta-keto ester moiety

Journal of the Brazilian Chemical Society, 2006
The rearrangement of beta,gamma-unsaturated esters, such as 2-(3,4-dihydronaphthalen-1-yl)-propionic acid ethyl ester, with thallium trinitrate (TTN) in acetic acid leads to 3-indan-1-yl-2-methyl-3-oxo-propionic acid ethyl ester in good yield, through a ...
Silva Jr. Luiz F., Pedrozo Eliane C., Ferraz Helena M. C.   +2 more
doaj  

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, Volume 603, Issue 15, Page 4255-4291, 1 August 2025.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Research progress of donepezil for treating mild to moderate Alzheimer's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
Donepezil is the second generation of cholinesterase inhibitors (ChEIs), which has a good effect on mild to moderate Alzheimer's disease (AD). In recent years, there were a lot of studies on the mechanism of donepezil. This paper mainly introduces the
Xin-xin LI, Yun-yun ZHANG, Bin WANG
doaj  

Tuning NIR Absorption and Emission of Diphenyl‐Dihydrophenazine‐Based Merocyanines with Ultra Narrow Band Gap

Chemistry – A European Journal, Volume 31, Issue 42, July 25, 2025.
Novel merocyanine derivatives with a strong diphenyl‐dihydrophenazine donor and a series of strong electron acceptors were developed. The indanone and indandione acceptor units were modified by dicyanovinylene groups to tune acceptor strength. Among these derivatives, DPPZ‐IDD realized an ultranarrow electrochemical gap of 0.93 eV and an optical band ...
Kateřina Teichmanová, Stanislav Luňák Jr., Karel Pauk, Lukáš Střižík, Zdeňka Růžičková, Tomáš Mikysek, Klára Melánová, Aleš Imramovský, Kazuhiko Nagura   +8 more
wiley   +1 more source

Hochgradig enantioselektive Organokatalyse mit zweizähnigen Halogenbrückendonoren

Angewandte Chemie, Volume 137, Issue 30, July 21, 2025.
In einer Mukaiyama‐Aldol‐Modellreaktion mit allgemeinen Substraten wurden hohe Enantioselektivitäten mit einem modifizierbaren, bidentaten Iod(I)‐basierten Halogenbrücken‐Organokatalysator erreicht. Die entscheidende Rolle der Halogenbrücken wurde durch das schlechte Abschneiden des entsprechenden Wasserstoffbrückendonors und durch DFT‐Berechnungen ...
Julian Wolf, Meghana Poliyodath Mohanan, Raphaël Robidas, Revannath L. Sutar, Elric Engelage, Claude Y. Legault, Stefan M. Huber   +6 more
wiley   +1 more source

Highly Enantioselective Organocatalysis with Bidentate Halogen Bond Donors

Angewandte Chemie International Edition, Volume 64, Issue 30, July 21, 2025.
In a model Mukaiyama aldol reaction with unbiased substrates, high enantioselectivity was achieved with a modifiable bidentate iodine(I)‐based halogen bonding organocatalyst. The crucial role of halogen bonding was confirmed by the low performance of the corresponding hydrogen bond donor and via DFT calculations.
Julian Wolf, Meghana Poliyodath Mohanan, Raphaël Robidas, Revannath L. Sutar, Elric Engelage, Claude Y. Legault, Stefan M. Huber   +6 more
wiley   +1 more source

1,1,3-Trimethyl-3-(4-nitrophenyl)indane [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
In the title compound, C(18)H(19)NO(2), the five-membered ring of the indane fragment adopts an envelope conformation, with the unsubstituted C atom, acting as the flap atom, deviating by 0.412 (3) Å from the plane through the remaining four atoms. The dihedral angle between the nitro-phenyl ring and the indane benzene ring is 72.5 (1)°.
Shi-Xu Yi, Fang Bo, Hua Chen, Guo-Wei Gao, Jian Men   +4 more
openaire   +3 more sources