Results 21 to 30 of about 1,835 (185)

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

Ipriflavone From Aquilaria malaccensis Lam. Exosome‐Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia‐Inducible Factor‐α (HIF‐α) Hydroxylation Thereby Alleviating Hypoxia‐Induced Gastrointestinal Mucosal Ferroptosis

MedComm, Volume 7, Issue 4, April 2026.
Ipriflavone (Ipr), an active component of Aquilaria malaccensis Lam. exosome‐like nanoparticles (AELNs), significantly reduces hypoxia‐inducible factor‐α (HIF‐α) expression by enhancing the prolyl hydroxylase domain protein 2 (PHD2)‐mediated hydroxylation of HIF‐α, thereby downregulating HIF‐α‐induced polyunsaturated fatty acid‐phospholipids (PUFA‐PLs),
Dezhi Wang, Xingchen Liao, Yilin Wang, Xuexin Wang, Heng Zhang, Jie Zeng, Mingjie Zhang, Xin Wang, Fangli Ren, Yinyin Wang, Meng Li, Wenchen Wang, Qing Lin, Lingyun Gu, Zhijie Chang, Jianqiu Sheng   +15 more
wiley   +1 more source

Dual‐Interface Engineered 2D/3D/2D Heterojunctions for Stable Inverted FACsPbI3 Perovskite Solar Cells

Small Structures, Volume 7, Issue 4, April 2026.
Dual‐interface engineering with 2‐AI‐2‐CMEH and TEACl yielded sequential 2D/3D heterostructures that optimized crystallization, passivated defects, and aligned energy levels. This approach boosted the PCE of MA‐free inverted perovskite solar cells (IPSCs) to 23.57% (from 19.26%), with an open‐circuit voltage of 1.116 V and a fill factor (FF) of 82.89%,
Ruibo Zhou, Shuang Li, Haoyun Dou, Zhou Yang, Rongjun Zhao, Xiaolu Zheng, Hongqing Ma, Hong‐En Wang   +7 more
wiley   +1 more source

N‐Insertion of Diazonium Salts Into Ketone Derivatives

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
Diazonium salts insert into ketones and their silyl enol ethers through a sequence of α‐azenylation and ring expansion via an N‐iminoaziridinium species. Coupled with an efficient N‐N bond cleavage, this protocol offers a mild alternative to Beckmann rearrangements and a powerful tool for skeletal editing of ketones.
Mohammed Anif Pasha, Jiwon Jang, Youngjin Bae, Seunghoon Shin   +3 more
wiley   +2 more sources

(E)-2-(4-Chlorobenzylidene)indan-1-one [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title compound, C16H11ClO, the dihedral angle between the almost planar dihydroindene ring system (r.m.s. deviation = 0.009 Å) and the chlorobenzene ring is 3.51 (14) °. In the crystal, mol ­ ecules are connected by C-H? O and weak C-H? Cl interactions, forming infinite layers parallel to (101).
Mohamed Ashraf Ali, Tan Soo Choon, Lim Yee Lan, Mohd Mustaqim Rosli, Hoong‐Kun Fun   +4 more
openaire   +3 more sources

Mesoionische N‐Heterocyclische Olefine, Imine, Thione, Phosphinidene und ihre Anwendung in der Katalyse

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
Dieser Mini‐Review behandelt die neuesten Fortschritte bei der Synthese, Reaktivität und metallfreien katalytischen Verwendung von mesoionischen N‐heterocyclischen Olefinen (mNHOs), Iminen (mNHIs), Thionen (mNHTs) und Phosphinidenen (mNHPs). Kurzzusammenfassung Übergangsmetallverbindungen sind allgemein für ihre Fähigkeit bekannt, kleine Moleküle zu ...
Subir Maji, Sreejyothi P., Max M. Hansmann, Swadhin K. Mandal   +3 more
wiley   +1 more source

Asymmetric Aziridination of Allylic Carbamates Using Ion‐Paired Rhodium Complexes and Extrapolation to C─H Amination of Phenethyl Carbamates

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
Aziridination of alkenes is an important route to chiral nitrogen‐containing building blocks. We report that carbamate‐functionalized allylic alcohols undergo highly enantioselective aziridination using achiral dimeric Rh complexes ion‐paired with cinchona alkaloid‐derived chiral cations.
Arthur R. Lit, Shotaro Takano, Christian Zachau, Ioana Băltărețu, Robert J. Phipps   +4 more
wiley   +2 more sources

Bioactive Indanes: Design, synthesis and bioactivity investigation of 2,2-substituted Indane derivatives, a new bioactive Indane scaffold

Bioorganic Chemistry
The indane scaffold, prevalent in bioactive natural products, underpins numerous therapeutics. Our group developed a series of 1,2-indane dimers, including PH46A (9), for inflammatory and autoimmune diseases. This study details the design, synthesis and characterisation of 21 compounds, including 2,2-disubstituted indanones (16a-16h), indanols (17a-17h)
Tao, Zhang, Kit, Chan, Abdulilah, Ece, Robin, Daly, Aoife, Cannon, Gaia A, Scalabrino, Neil, Frankish, Jacintha, O'Sullivan, Padraig, Fallon, Helen, Sheridan   +9 more
openaire   +2 more sources

Mesoionic N‐Heterocyclic Olefins, Imines, Thiones, Phosphinidenes and Their Application in Catalysis

Angewandte Chemie International Edition, Volume 65, Issue 3, 16 January 2026.
This minireview covers recent advances in the synthesis, reactivity, and metal‐free catalytic uses of mesoionic N‐heterocyclic olefins (mNHOs), imines (mNHIs), thiones (mNHTs), and phosphinidenes (mNHPs). Abstract Transition metal compounds are widely known for their ability to activate small molecules and are excellent catalysts for a wide range of ...
Subir Maji, Sreejyothi P, Max M. Hansmann, Swadhin K. Mandal   +3 more
wiley   +1 more source

The reaction of 1-tetralones with thallium trinitrate supported on clay: ring contraction vs a-oxidation

Journal of the Brazilian Chemical Society, 2001
The reaction of a series of 1-tetralones with thallium trinitrate supported on Montmorillonite K-10 clay led to products of ring contraction (methyl indan-1-carboxylates) and/or alpha-oxidation (2-methoxy-1-tetralones), in variable yields.
Ferraz Helena M. C., Silva Jr. Luiz F., Aguilar Andrea M., Vieira Tiago O.   +3 more
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