Results 11 to 20 of about 1,131 (142)

Update of the risk assessment on emerging and novel brominated flame retardants in food

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to update its 2012 risk assessment on Emerging and Novel brominated flame retardants (BFRs) in food. Since the previous Opinion, further information was collected for a total of 27 BFRs. The CONTAM Panel concluded that TDBPP, DBPNG and TBNPA are considered genotoxic and carcinogenic.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Emilio Benfenati, Diane Benford, Andy Hart, Martin Rose, Henri Schroeder, Christiane Vleminckx, Martine Vrijheid, Edoardo Carnesecchi, Violetta Costanzo, Andrea Gissi, Eirini Kouloura, Luisa Ramos Bordajandi, Francesca Riolo, Christer Hogstrand   +33 more
wiley   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

Ipriflavone From Aquilaria malaccensis Lam. Exosome‐Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia‐Inducible Factor‐α (HIF‐α) Hydroxylation Thereby Alleviating Hypoxia‐Induced Gastrointestinal Mucosal Ferroptosis

MedComm, Volume 7, Issue 4, April 2026.
Ipriflavone (Ipr), an active component of Aquilaria malaccensis Lam. exosome‐like nanoparticles (AELNs), significantly reduces hypoxia‐inducible factor‐α (HIF‐α) expression by enhancing the prolyl hydroxylase domain protein 2 (PHD2)‐mediated hydroxylation of HIF‐α, thereby downregulating HIF‐α‐induced polyunsaturated fatty acid‐phospholipids (PUFA‐PLs),
Dezhi Wang, Xingchen Liao, Yilin Wang, Xuexin Wang, Heng Zhang, Jie Zeng, Mingjie Zhang, Xin Wang, Fangli Ren, Yinyin Wang, Meng Li, Wenchen Wang, Qing Lin, Lingyun Gu, Zhijie Chang, Jianqiu Sheng   +15 more
wiley   +1 more source

Dual‐Interface Engineered 2D/3D/2D Heterojunctions for Stable Inverted FACsPbI3 Perovskite Solar Cells

Small Structures, Volume 7, Issue 4, April 2026.
Dual‐interface engineering with 2‐AI‐2‐CMEH and TEACl yielded sequential 2D/3D heterostructures that optimized crystallization, passivated defects, and aligned energy levels. This approach boosted the PCE of MA‐free inverted perovskite solar cells (IPSCs) to 23.57% (from 19.26%), with an open‐circuit voltage of 1.116 V and a fill factor (FF) of 82.89%,
Ruibo Zhou, Shuang Li, Haoyun Dou, Zhou Yang, Rongjun Zhao, Xiaolu Zheng, Hongqing Ma, Hong‐En Wang   +7 more
wiley   +1 more source

N‐Insertion of Diazonium Salts Into Ketone Derivatives

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
Diazonium salts insert into ketones and their silyl enol ethers through a sequence of α‐azenylation and ring expansion via an N‐iminoaziridinium species. Coupled with an efficient N‐N bond cleavage, this protocol offers a mild alternative to Beckmann rearrangements and a powerful tool for skeletal editing of ketones.
Mohammed Anif Pasha, Jiwon Jang, Youngjin Bae, Seunghoon Shin   +3 more
wiley   +2 more sources

Mesoionische N‐Heterocyclische Olefine, Imine, Thione, Phosphinidene und ihre Anwendung in der Katalyse

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
Dieser Mini‐Review behandelt die neuesten Fortschritte bei der Synthese, Reaktivität und metallfreien katalytischen Verwendung von mesoionischen N‐heterocyclischen Olefinen (mNHOs), Iminen (mNHIs), Thionen (mNHTs) und Phosphinidenen (mNHPs). Kurzzusammenfassung Übergangsmetallverbindungen sind allgemein für ihre Fähigkeit bekannt, kleine Moleküle zu ...
Subir Maji, Sreejyothi P., Max M. Hansmann, Swadhin K. Mandal   +3 more
wiley   +1 more source

Asymmetric Aziridination of Allylic Carbamates Using Ion‐Paired Rhodium Complexes and Extrapolation to C─H Amination of Phenethyl Carbamates

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
Aziridination of alkenes is an important route to chiral nitrogen‐containing building blocks. We report that carbamate‐functionalized allylic alcohols undergo highly enantioselective aziridination using achiral dimeric Rh complexes ion‐paired with cinchona alkaloid‐derived chiral cations.
Arthur R. Lit, Shotaro Takano, Christian Zachau, Ioana Băltărețu, Robert J. Phipps   +4 more
wiley   +2 more sources

Mesoionic N‐Heterocyclic Olefins, Imines, Thiones, Phosphinidenes and Their Application in Catalysis

Angewandte Chemie International Edition, Volume 65, Issue 3, 16 January 2026.
This minireview covers recent advances in the synthesis, reactivity, and metal‐free catalytic uses of mesoionic N‐heterocyclic olefins (mNHOs), imines (mNHIs), thiones (mNHTs), and phosphinidenes (mNHPs). Abstract Transition metal compounds are widely known for their ability to activate small molecules and are excellent catalysts for a wide range of ...
Subir Maji, Sreejyothi P, Max M. Hansmann, Swadhin K. Mandal   +3 more
wiley   +1 more source

Experimental and Analytical Tools for the Chemical Recycling of Engineering Plastics – A Multi‐Scale Pyrolysis Study on Polydicyclopentadiene

Macromolecular Rapid Communications, Volume 46, Issue 23, December 5, 2025.
The presented work demonstrates the importance of a comprehensive assessment of engineering plastics pyrolysis on the example of Polydicyclopentadiene. Analyses in µg‐, mg‐, and lab‐scale provide insight into mechanisms, yields, and products. An analytical and experimental toolset is showcased, by which the foundation for the assessment of pyrolysis as
Michael Zeller, Salar Tavakkol, Dieter Stapf   +2 more
wiley   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source