Results 51 to 60 of about 476 (184)
PJA2 Suppresses Colorectal Cancer Progression by Controlling HDAC2 Degradation and Stability
Advanced Science, Volume 12, Issue 13, April 3, 2025.PJA2, an E3 ubiquitin‐protein ligase, actively restrains colorectal cancer (CRC) progression. It targets histone deacetylase 2 (HDAC2) for degradation, which in turn activates the interferon‐induced protein with tetratricopeptide repeats (IFIT) family, effectively hindering tumor growth and promoting apoptosis.
Zhihao Chen +13 more
wiley +1 more source
Molecular and clinical determinants of drug-induced long QT syndrome: an iatrogenic channelopathy. [PDF]
, 2004 More than 70 drugs present on the Swiss market can cause drug-induced long QT syndrome (LQTS), which is associated with torsades de pointes (TdP) arrhythmias, potentially leading to sudden cardiac death. Basic and clinical investigations performed during
Abriel, H. +7 more
core
Case Reports in Psychiatry, Volume 2025, Issue 1, 2025.Background: Neuroleptic malignant syndrome (NMS) is an idiosyncratic and life‐threatening side effect that usually occurs in response to dopamine receptor antagonist medications. Despite increased awareness, the diagnosis of NMS remains challenging due to its wide differential diagnoses, which can lead to delayed treatment and increased mortality or ...
Forouzan Elyasi +4 more
wiley +1 more source
Dyslipidemia Induced by Drugs Used for the Prevention and Treatment of Vascular Diseases [PDF]
Dyslipidemia is a major vascular risk factor. Interestingly, several agents used for the prevention and treatment of vascular diseases have an adverse effect on the lipid profile. In addition, agents belonging to the same class (e.g.
Athyros, Vasilios G +3 more
core +2 more sources
Single-pill combination of indapamide and perindopril: potential of practical application [PDF]
The effectiveness of blood pressure control can be increased with the use of single-pill combinations. When choosing an agent, the evidence of its components should be focused.
A. M. Kochergina, V. V. Kashtalap
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Arzneimittelinformation und Arzneimitteltherapiesicherheit mit Fokus auf QT-Intervall-verlängernde Arzneistoffe in Deutschland [PDF]
, 2023 Background and Objectives The Summary of Product Characteristics (SmPC) / Prescribing Information (PI) is one of the most important sources of information for doctors and pharmacists when prescribing and dispensing drugs and forms the basis for the ...
Then, Melanie
core +1 more source
Рациональная фармакотерапия в кардиологии, 2015 Aim. To compare the dynamics of intrarenal vascular resistance (IRVR), circadian blood pressure (BP) profile and glomerular filtration rate (GFR) in patients with arterial hypertension (HT) and type 2 diabetes mellitus (DM) who achieved the target BP ...
O. A. Koshel'skaya, O. A. Zhuravleva
doaj +3 more sources
ORIGINAL Programme: study background and design
Кардиоваскулярная терапия и профилактика, 2010 The paper presents the design of the ORIGINAL Programme (substituting indapamide generics with arifon retard in patients with arterial hypertension), evaluating blood pressure (BP) reduction in arterial hypertension (AH) patients starting the treatment ...
Yu. A. Karpov
doaj
Diuretics in patients with metabolic disturbances
Кардиоваскулярная терапия и профилактика, 2007 Aim. To study antihypertensive effectiveness of indapamide retard, its effects on carbohydrate, lipid, purine, electrolyte metabolism in patients with mild arterial hypertension (AH) and metabolic syndrome (MS). Material and methods.
I. E. Chazova, V. B. Mychka
doaj
Diuretics in arterial hypertension: angels and demons
Российский кардиологический журнал, 2013 This paper compares the results of multiple studies on antihypertensive diureticsand various clinical parameters in patients with arterial hypertension, includingvascular stiffness, end-points, hypotensive effects, organ protection, potassiumlevels, and ...
S. V. Nedogoda
doaj +1 more source