Results 91 to 100 of about 7,519 (213)

Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

, 2018
An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2 H -indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations.
Mallik, Bhabani Shankar, Gorantla, Koteswar Rao, Murugan, Arumugavel, D S, Sharada, Gorantla, Koteswar, Murugan, A   +5 more
core   +1 more source

3-Bromo-6-nitro-1-(prop-2-en-1-yl)-1H-indazole

IUCrData, 2018
The asymmetric unit of the title compound, C10H8BrN3O2, contains two independent molecules differing primarily in the orientations of the allyl substituents [N—C—C=C torsion angles = −125.4 (16) and 116.0 (16)°].
Mohamed Mokhtar Mohamed Abdelahi, Youness El Bakri, Mohammed Benchidmi, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

Indazole Derivatives: Promising Anti-tumor Agents

, 2019
Background: Currently, cancer continues being a dramatically increasing and serious threat to public health. Although many anti-tumor agents have been developed in recent years, the survival rate of patients is not satisfactory.
Shengzhuo He, Wei Li, Zilong Tang, Yichao Wan   +3 more
core   +1 more source

Synthesis and Characterization of Novel Indazole–Sulfonamide Compounds with Potential MAPK1 Inhibitory Activity for Cancer Treatment

Molbank
Indazoles are a very important group of nitrogen-containing heterocycles with a wide range of biological and medicinal applications. These properties make them highly attractive for drug development, particularly when combined with sulfonamides to ...
Nassima Saghdani, Abdelali Chihab, Nabil El Brahmi, Saïd El Kazzouli   +3 more
doaj   +1 more source

Synthesis and antiproliferative activity of indazole derivatives

, 2011
Indazole nucleus represents a very attractive scaffol to obtain new molecole endowed with antineoplastic activity. On the basis of these literature data we have designed some indazole derivatives such as N-indazolylbenzamides and N-indazolyl-N ...
RAIMONDI, Maria Valeria, PLESCIA, Fabiana, DAIDONE, Giuseppe, CASCIOFERRO, Stella Maria, MAGGIO, Benedetta, RAFFA, Demetrio, Tolomeo, M   +6 more
core  

3-ethenyl-1H-indazole

, 2019
This dataset contains experimental data from a sample (3-ethenyl-1H-indazole, InChI=1S/C9H8N2/c1-2-8-7-5-3-4-6-9(7)11-10-8/h2-6H,1H2,(H,10,11)).
Huang, Yu-Chieh
core   +1 more source

Benzothiazole–Triazole–Indazole Conjugates: Design, Characterization, and Preliminary In Vitro MTT-Based Antiproliferative Evaluation

Molecules
A new library of benzothiazole–triazole–indazole conjugates (5a–s) was efficiently synthesized via a Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) strategy.
Fatima E. Laghchioua, Maurizio Viale, Renata Silva, Fernando Remião, José A. S. Cavaleiro, M. Amparo F. Faustino, El Mostapha Rakib, Maria Graça P. M. S. Neves, Nuno M. M. Moura   +8 more
doaj   +1 more source

SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF 3-AMINO-N-PHENYL-1H-INDAZOLE-1-CARBOXAMIDES

, 2010
Recently our research group has reported the synthesis of some 3-amino-N-phenyl-1H-indazole-1-carboxamides able to inhibit at low micromolar concentrations the cell growth of many neoplastic cell lines.
RAIMONDI, Maria Valeria, PLESCIA, Fabiana, DAIDONE, Giuseppe, CASCIOFERRO, Stella Maria, PIPITONE, Rosaria Maria, MAGGIO, Benedetta, PLESCIA, Salvatore, GRIMAUDO, Stefania, RAFFA, Demetrio, Tolomeo, M, DI CRISTINA, Antonietta   +10 more
core  

The crystal structure of CYP2E1 complexed with indazole.

, 2012
The major helices are labeled. Heme is shown as black spheres; indazole is shown as magenta sticks. All figures were generated with Pymol.
Weihua Li (144468), Zhonghua Shen (177885), Feixiong Cheng (151564), Yun Tang (151578), Guixia Liu (151574), You Xu (177889), Jie Shen (31533), Wen Xiao (157684), Jing Fu (177892)   +8 more
core   +1 more source

Assessing Specificity of Indazole Derivatives as Inhibitors to CYP2E1 [PDF]

, 2018
Metabolism of drugs in the human body can yield both desirable and undesirable results. Some of these side-effects are due to drug-drug interactions, drug-diet interactions, or lack of drug specificity.
Hart, Hannah
core