Results 51 to 60 of about 515,254 (287)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Energies, 2023 This research focuses on exploring various techniques and models for simulating the random behavior of energy facilities or systems. These simulations are essential in identifying the likelihood of component failures within the studied facilities.
Ivan Postnikov +4 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Volcanic hazard assessment for the Canary Islands (Spain) using extreme value theory [PDF]
Natural Hazards and Earth System Sciences, 2011 The Canary Islands are an active volcanic region densely populated and visited by several millions of tourists every year. Nearly twenty eruptions have been reported through written chronicles in the last 600 yr, suggesting that the probability of a new ...
R. Sobradelo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Quantum signatures of chaos from free probability
Journal of High Energy PhysicsA classical dynamical system can be viewed as a probability space equipped with a measure-preserving time evolution map, admitting a purely algebraic formulation in terms of the algebra of bounded functions on the phase space.
Hugo A. Camargo +4 more
doaj +1 more source
Information Structures for Causally Explainable Decisions
Entropy, 2021 For an AI agent to make trustworthy decision recommendations under uncertainty on behalf of human principals, it should be able to explain why its recommended decisions make preferred outcomes more likely and what risks they entail.
Louis Anthony Cox
doaj +1 more source
Cumulants, Spreadability and the Campbell-Baker-Hausdorff Series
, 2019 We define spreadability systems as a generalization of exchangeability systems in order to unify various notions of independence and cumulants known in noncommutative probability.
Hasebe, Takahiro, Lehner, Franz
core +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Towards an Information Retrieval Theory of Everything [PDF]
, 2009 I present three well-known probabilistic models of information retrieval in tutorial style: The binary independence probabilistic model, the language modeling approach, and Google's page rank.
Hiemstra, Djoerd
core +2 more sources