Results 151 to 160 of about 580 (262)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Dental, Oral and General Health of Geriatric In-Hospital Patients Before Immediate Prosthetic Treatment: A Retrospective Cohort Study. [PDF]

Dent J (Basel)
Pampel M, Kraft J, Tümena T, Kraft JW.
europepmc   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Some Financial Problems of State Enterprises

, 1968
The notion of "khozraschet" appeared in Soviet economy in the period of far-reaching centralization. It meant then a combination of central management of the state enterprises with some degree of their freedom in the fulfilment of commitments to ...
Wierzbicki, Janusz
core  

Tracing metallurgical links and silver provenance in Balkan coinage (5th -1st centuries BCE). [PDF]

Archaeol Anthropol Sci
Westner KJ, Blichert-Toft J, Gentelli L, Pavlovska E, de Callataÿ F, Albarède F.   +5 more
europepmc   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Sex differences in ectopic lipid deposits and cardiac function across a wide range of glycemic control: a secondary analysis. [PDF]

Obesity (Silver Spring)
Harreiter J, Just I, Weber M, Klepochová R, Bastian M, Winhofer Y, Wolf P, Scherer T, Leutner M, Kosi-Trebotic L, Deischinger C, Chmelík M, Krebs MR, Trattnig S, Krššák M, Kautzky-Willer A.   +15 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

A novel social-network-analysis-based approach for analyzing complex network of actors involved in accessibility of anti-cancer medications in Iran. [PDF]

Health Res Policy Syst
Lankarani KB, Zarei L, Alinezhad E, Sadeghdoost A.   +3 more
europepmc   +1 more source

Mini-Batch Alignment: A Deep-Learning Model for Domain Factor-Independent Feature Extraction for Wi-Fi-CSI Data. [PDF]

Sensors (Basel), 2023
van Berlo B, Oerlemans C, Marogna FL, Ozcelebi T, Meratnia N.   +4 more
europepmc   +1 more source