Results 161 to 170 of about 18,422 (311)

Intracellular Reactive Oxygen Species Generation Induced by High‐Frequency Ultrasound in Thickness Vibration Mode

open access: yesAdvanced Science, EarlyView.
Cell‐sized high‐frequency ultrasound using a lithium niobate transducer, previously ignored in reactive oxygen species (ROS) production, generated intracellular ROS at frequencies higher than conventionally used. The intracellular generation of ROS by cell‐sized high‐frequency ultrasound revealed in this study is expected to be applied to innovative ...
Kotaro Fujishiro   +4 more
wiley   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu   +13 more
wiley   +1 more source

THE PRINCIPLES OF THE EUROPEAN PUBLIC SERVICES LAW [PDF]

open access: yes
European civil service law has emerged as an independent law branch relatively recently. At the EU level there were three categories of rules that regulate the public employees’ activity, according tothe treaty type that established one of the top three ...
Ana-Maria Bercu, Mihaela Tofan
core  

Severity, Outcomes, and their Secular Changes in 33,870 Ischemic Stroke Patients with Atrial Fibrillation in a Hospital-Based Registry: Japan Stroke Data Bank. [PDF]

open access: yesJ Atheroscler Thromb
Toyoda K   +18 more
europepmc   +1 more source

A novel nuclear receptor subfamily enlightens the origin of heterodimerization. [PDF]

open access: yesBMC Biol, 2022
Beinsteiner B   +15 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

open access: yesAdvanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang   +11 more
wiley   +1 more source

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