Results 11 to 20 of about 16,633,381 (293)

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion [PDF]

Immunity, 2020
Summary Type I interferon (IFN) response is commonly recognized as the main signaling activity of STING. Here, we generated the Sting1S365A/S365A mutant mouse that precisely ablated IFN-dependent while preserving IFN-independent activities of Sting ...
Nan Yan, Kun Yang, Nicole Dobbs
exaly   +3 more sources

Antioxidant-independent activities of alpha-tocopherol. [PDF]

J Biol Chem
Alpha-tocopherol (vitamin E) is a plant-derived dietary lipid that is essential for the health of most animals, including humans. Originally discovered as a fertility factor in rodents, the primary health-promoting properties of the vitamin in humans was
Chen M, Ghelfi M, Poon JF, Jeon N, Boccalon N, Rubsamen M, Valentino S, Mehta V, Stamper M, Tariq H, Zunica E, Ulatowski L, Chung S, Fritz C, Cameron M, Cameron C, Pratt DA, Atkinson J, Finno CJ, Manor D.   +19 more
europepmc   +5 more sources

Home Literacy Activities and Children’s Reading Skills, Independent Reading, and Interest in Literacy Activities From Kindergarten to Grade 2

Frontiers in Psychology, 2020
According to the Home Literacy Model (Sénéchal and LeFevre, 2002, 2014), young children can be exposed to two distinct types of literacy activities at home.
Gintautas Silinskas, Monique Sénéchal, Minna Torppa, Marja-Kristiina Lerkkanen   +3 more
doaj   +4 more sources

Relationship between Children's Independent Activities and the Built Environment of Outdoor Activity Space in Residential Neighborhoods: A Case Study of Nanjing. [PDF]

Int J Environ Res Public Health, 2022
Children are a vulnerable population that is frequently overlooked in urban planning. The spatial demands of children are garnering broader consideration in the development of public spaces in cities as efforts to promote child-friendly cities.
Zhou Y, Wang M, Lin S, Qian C.
europepmc   +2 more sources

RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a

Cell Reports, 2017
CRISPR-Cas systems provide bacteria and archaea with sequence-specific protection against invading mobile genetic elements. In the presence of divalent metal ions, Cas9 and Cas12a (formerly Cpf1) proteins target and cleave DNA that is complementary to a ...
Ramya Sundaresan, Hari Priya Parameshwaran, S.D. Yogesha, Mark Walter Keilbarth, Rakhi Rajan   +4 more
doaj   +4 more sources

CHD7 regulates cardiovascular development through ATP-dependent and -independent activities. [PDF]

Proc Natl Acad Sci U S A, 2020
Significance Mutation of CHD7 causes multiple developmental disorders, including CHARGE syndrome, in which conotruncal anomalies are the most prevalent form of heart defects.
Yan S, Thienthanasit R, Chen D, Engelen E, Brühl J, Crossman DK, Kesterson R, Wang Q, Bouazoune K, Jiao K.   +9 more
europepmc   +2 more sources

Yeast and Filaments Have Specialized, Independent Activities in a Zebrafish Model of Candida albicans Infection. [PDF]

Infect Immun, 2018
Candida albicans dimorphism is a crucial virulence factor during invasive candidiasis infections, which claim the lives of nearly one-half of those afflicted.
Seman BG, Moore JL, Scherer AK, Blair BA, Manandhar S, Jones JM, Wheeler RT.   +6 more
europepmc   +2 more sources

c-Jun N-terminal kinases differentially regulate TNF- and TLRs-mediated necroptosis through their kinase-dependent and -independent activities. [PDF]

Cell Death Dis, 2018
Tumor necrosis factor (TNF) and Toll-like receptor (TLR)3/TLR4 activation trigger necroptotic cell death through downstream signaling complex containing receptor-interacting protein kinase 1 (RIPK1), RIPK3, and pseudokinase mixed lineage kinase-domain ...
Cao M, Chen F, Xie N, Cao MY, Chen P, Lou Q, Zhao Y, He C, Zhang S, Song X, Sun Y, Zhu W, Mou L, Luan S, Gao H.   +14 more
europepmc   +2 more sources

nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor. [PDF]

Sci Rep, 2017
Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr).
Facchinello N, Skobo T, Meneghetti G, Colletti E, Dinarello A, Tiso N, Costa R, Gioacchini G, Carnevali O, Argenton F, Colombo L, Dalla Valle L.   +11 more
europepmc   +2 more sources

Two independent activities define Ccm1p as a moonlighting protein in Saccharomyces cerevisiae [PDF]

Bioscience Reports, 2012
Ccm1p is a nuclear-encoded PPR (pentatricopeptide repeat) protein that localizes into mitochondria of Saccharomyces cerevisiae. It was first defined as an essential factor to remove the bI4 [COB (cytochrome b) fourth intron)] and aI4 [COX1 (cytochrome c ...
J. Ignacio Moreno, Babu Patlolla, Kerry R. Belton, Brenita C. Jenkins, Polina V. Radchenkova, Marta A. Piva   +5 more
doaj   +2 more sources