Results 121 to 130 of about 7,147,780 (265)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Cartografía Colombia en un tambor
Esta cartografía presenta un recorrido por la riqueza y diversidad de tambores y expresiones musicales que narran nuestra historia y nuestra fuerza vital.
Bogotá : Corporación Cultural Cabildo
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Investigating the Factors Influencing Non-Marriage among Single People in Kermanshah City, Iran, in 2023 [PDF]
تحقیقات نظام سلامتBackground: Marriage is one of the most complex human relationships and plays a fundamental role in the daily lives of adults. For this purpose, the present study was conducted with the aim of determining the factors affecting the non-marriage of single ...
Babak Moeini +4 more
doaj
Frontiers in PsychologyEmotional intelligence (EI) has emerged as a pivotal construct in educational psychology; however, understanding of how physical education (PE) contributes to its development remains fragmented.
Jiayin Lin, Huanling Ma
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Cultural change in telecommunications companies: a case study
, 2014 This work aims to propose a model for the conduct of cultural change in the IT department of a company in the telecommunications industry. To achieve the goal proposed exploratory, technical procedures used were the case study and literature review.
Irion, Crishna +2 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Comparative Cultural Diplomacy: China Cultural Centers in Europe (Hungary) and Africa (Morocco) [PDF]
openThis study analyzes the cultural diplomacy activities of Chinese cultural centers in Europe (Hungary) and Africa (Morocco) using a comparative case study approach.
CHEN, ZHISHAN
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