Results 101 to 110 of about 7,147,780 (265)
Texas Panhandle Centers [Agency Newsletter]
, 2019 Monthly newsletter discussing news and events related to the Texas Panhandle Centers Behavioral and Development Health and other information about mental ...
Texas Panhandle Centers Behavioral and Development Health
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Texas Panhandle Centers [Agency Newsletter]
Monthly newsletter discussing news and events related to the Texas Panhandle Centers Behavioral and Development Health and other information about mental ...
Texas Panhandle Centers Behavioral and Development Health
core +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Voting for a democratic South Africa needs an independent authority to put it all together [PDF]
, 1994 462.B.2.3(17).pdf created from the media publications in the SA Election material Collection MS 462, held in the Manuscripts Section of the Stellenbosch Library and Information Service.Voting for a democratic South Africa needs an independent authority ...
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Slip-painted Pottery (Types, Widespread, Dating) [PDF]
نگره, 2012 About two centuries after the appearance of Islam, the production of potteries were gradually changing through Islamic world. At eastern parts these changes were taking place coincident with Iranian movements and establishment of independent dynasties ...
Morteza Ataie +2 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source