Results 131 to 140 of about 11,106,432 (291)

Γ-independent dominating graphs of paths and cycles [PDF]

Songklanakarin Journal of Science and Technology (SJST)
A set D of vertices in a graph G is an independent dominating set if D is a set of pairwise nonadjacent vertices of G such that every vertex of G not in D is adjacent to at least one vertex in D.
Roongrat Samanmoo, Nantapath Trakultraipruk   +1 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Strongly i-Bicritical Graphs

Theory and Applications of Graphs
A graph $G$ is \emph{strongly $i$-bicritical} if it has independent domination number $i(G) \geq 3$, and $i(G - \{x, y\}) = i(G) - 2$ whenever $x$ and $y$ are two non-adjacent vertices of $G$.
Michelle Edwards, Gary MacGillivray, Shahla Nasserasr   +2 more
doaj   +1 more source

Bounds for the ratio between the domination number and the independent domination number

In this article we present new and improved results for the ratio between the independent domination number and the domination number in graphs with bounded degree. We present a general formula, that, for a fixed maximum degree, allows to compute an upper bound for this ratio as a function of an upper bound $β|V|$ for the independent domination number.
Brinkmann, Gunnar, Van Overberghe, Steven   +1 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Independent Domination in Complementary Prisms

, 2013
The complementary prism of a graph G is the graph formed from a disjoint union of G and its complement ̄G by adding the edges of a perfect matching between the corresponding vertices of G and G.
Haynes, Teresa W., Góngora, Joel A., Jum, Ernest   +2 more
core   +1 more source

Independent Bondage Number in Planar Graphs Under Girth Constraints

Mathematics
Given a finite, simple, connected graph G with at least one edge, the independent bondage number bi(G) of G is the minimum size of an edge set, such that its deletion results in a graph with a strictly larger independent domination number than that of G.
E. G. K. M. Gamlath, Andrew Pham, Bing Wei   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source