Results 91 to 100 of about 2,524,223 (282)
Solving the Optimal Mistuning Problem by Symmetry: A General Framework for Extending Flutter Boundaries in Turbomachines via Mistuning [PDF]
, 1997 A general framework is presented for analyzing and optimizing stability increases due to mistuning. The framework given is model independent and is based primarily on symmetry arguments.
Shapiro, Benjamin
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Multi-modal Blind Source Separation with Microphones and Blinkies
, 2019 We propose a blind source separation algorithm that jointly exploits measurements by a conventional microphone array and an ad hoc array of low-rate sound power sensors called blinkies.
Ono, Nobutaka, Scheibler, Robin
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Application of the p-version of the finite-element method to global-local problems [PDF]
A brief survey is given of some recent developments in finite-element analysis technology which bear upon the three main research areas under consideration in this workshop: (1) analysis methods; (2) software testing and quality assurance; and (3 ...
Szabo, Barna A.
core +1 more source
, 2012 In this paper, a psychologically-inspired binary cascade classification schema is proposed for speech emotion recognition. Performance is enhanced because commonly confused pairs of emotions are distinguishable from one another.
A. Austermann +65 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
A Stock Market Prediction Method Based on Support Vector Machines (SVM) and Independent Component Analysis (ICA) [PDF]
Database Systems Journal, 2016 The research presented in this work focuses on financial time series prediction problem. The integrated prediction model based on support vector machines (SVM) with independent component analysis (ICA) (called SVM-ICA) is proposed for stock market ...
Hakob GRIGORYAN
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source