Results 121 to 130 of about 13,067,159 (317)

Two-stage index computation for bandits with switching penalties I : switching costs [PDF]

open access: yes, 2007
This paper addresses the multi-armed bandit problem with switching costs. Asawa and Teneketzis (1996) introduced an index that partly characterizes optimal policies, attaching to each bandit state a "continuation index" (its Gittins index) and a ...
Niño Mora, José
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Global Leaf Area Index from Field Measurements, 1932-2000

open access: green, 2012
Gregory P. Asner   +2 more
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Index

open access: yesNippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2018
openaire   +6 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Stress Among Doctors Doing Residency: A Cross-Sectional Study at A Tertiary Care Hospital in The City of Mumbai

open access: yesNational Journal of Community Medicine, 2015
Background: The workload of a tertiary care teaching hospital in a metropolitan city is tremendous. Resident doctors in these health care facilities bear the over whelming burden.
Aarti G Sahasrabuddhe   +2 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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