Results 241 to 250 of about 2,505,256 (301)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Development and application of a core competency evaluation index system for pediatric asthma specialist nurses in China: a mixed-method study. [PDF]

BMC Nurs
Qin Y, Cai X, Ji Y, Lu J, Zhang C, Gao Y, Yan S, Chen R, Huang R, Ma L, Chun X, Yan F.   +11 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Construction of an Index System of the Biosafety Incident Response Capability for Nursing Staff: A Delphi Study. [PDF]

Nurs Open
Wu C, Hu M, Zhang X, Fu M, Li L, Xu Q, Guo X, Lang H.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

SYSTEM INDEX

, 1982
openaire   +1 more source

Development and validation of an index system for caregiving capacity of family caregivers in caring for older adults with disabilities at home: a Delphi and Analytic Hierarchy Process. [PDF]

BMC Nurs
Suo S, Jiao J, Li Y, Gu J, Guo S, Liu C, Wang S, Wang P, Wang P.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Construction of the Competency Index System for Nursing Staff in Tertiary General Hospitals to Respond to Emerging Infectious Diseases. [PDF]

Healthcare (Basel)
Li M, Zhi C, Chen D, Ma Z, Zhu M, Ma Y, Ma H.   +6 more
europepmc   +1 more source

Author Correction: The construction of a physical literacy assessment index system for junior high school students: a Chinese study. [PDF]

Sci Rep
Gao M, Che W, Qi S.
europepmc   +1 more source