Results 71 to 80 of about 48,886 (295)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Termination of derivations for minimal tense logic
Lietuvos Matematikos Rinkinys, 2009 It is known that loop checking and backtracking are extensively used in various non-classical logics. An efficient loop checking is obtained using a technique based on histories.
Regimantas Pliuškevičius
doaj +1 more source
Expectations of linear functions with respect to truncazted multinormal distributions, with applications for uncertainty analysis in environmental modelling [PDF]
Uncertainty can hamper the stringency of commitments under cap and trade schemes. We assess how well intensity targets, where countries' permit allocations are indexed to future realised GDP, can cope with uncertainties in a post-Kyoto international ...
Jason J. Sharples, John C. V. Pezzey
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Para entender os índices de preços: uma visão moderna
Revista de Economia Mackenzie, 2004 Since the 1960s, when the “indexation of financial operations” was implemented in Brazil, a hot item of discussion has been the most appro p r i a t e d index that should be used for monetary correction of values, in a highly i n f l a t i o n a ry ...
Janes Ângelo de Souza
doaj
Inflation persistence, Price Indexation and Optimal Simple Interest Rate Rules [PDF]
We study the properties of the optimal nominal interest rate policy under different levels of price indexation. In our model indexation regulates the sources of inflation persistence.
Guido Ascari, Nicola Branzoli
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A prática de indexação: análise da evolução de tendências teóricas e metodológicas
TransinformaçãoAlmejando contribuir com uma reflexão sobre a prática do indexador e tendo em vista a evolução do processo de indexação, os autores procuram identificar, pela revisão da literatura, o desenvolvimento teórico e metodológico de tal processo, extraindo as ...
Maria dos Remédios da Silva +1 more
doaj
A persistência da indexação no Brasil pós-Real
Brazilian Journal of Political Economy, 2014 The paper analyzes the shortcomings of the Real Plan combining political science and economics, considering evidences on difficulties in implementing a complete plan of deindexation, namely: the distributional conflict, the corporatist relations between ...
André Roncaglia de Carvalho
doaj +1 more source
Indexed Versus Nominal Government Debt Under Inflation and Price-Level Targeting [PDF]
This paper presents a DSGE model in which long run inflation risk matters for social welfare. Optimal indexation of long-term government debt is studied under two monetary policy regimes: inflation targeting (IT) and price-level targeting (PT). Under IT,
Hatcher, M.
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