Results 121 to 130 of about 175,352 (225)

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

EDA Complex–Mediated C(sp3)–H Cross‐Dehydrogenative Coupling Enables Synthesis of Noncanonical α,β‐Diamino Acids

European Journal of Organic Chemistry, EarlyView.
Access to nonproteinogenic α,β‐diamino acids from simple feedstock precursors is of great interest to generate medicinal small molecule libraries. We report a regioselective photoinduced C(sp3)–C(sp3) cross‐dehydrogenative coupling (CDC) of N‐arylglycine derivatives with amides.
Krishnakumar Sachidanandan, Cole Stenftenagel, Athul Joshy, Alexander M. Cluff, Sébastien Laulhé   +4 more
wiley   +1 more source

Evaluation of the Accuracy of Probabilistic Record Linkage Across Sociodemographic Categories in 4 Databases: Exploratory Study. [PDF]

JMIR Form Res
Barboi C, Ouyang F, Lembcke L, Martin A, Griffith A, Allen KS, Li X, Xu H, Grannis SJ.   +8 more
europepmc   +1 more source

Improvement of Peak Integration in Capillary Electrophoresis: Reference Data Set No. 1

ELECTROPHORESIS, EarlyView.
ABSTRACT Capillary electrophoresis (CE) often provides superior separation of macromolecules such as monoclonal antibodies (mAbs), a major biopharmaceutical class, compared with liquid chromatography. However, electropherograms frequently exhibit complex baselines and peak shapes that are not reliably handled by integration algorithms designed for ...
Marlon Krompholz, Timothy Blanc, Huixin Lu, Patricia Christensen, Frédéric Ginot, Gábor Járvás, Trang D. Nguyen, Ashley Prout, Timothy Riehlman, Brian Wei, Andrei Hutanu, Steffen Kiessig, Knut Baumann, Cari E. Sänger‐van de Griend, Hermann Wätzig   +14 more
wiley   +1 more source

rTCT: Rodent Triangle Completion Task to Facilitate Reverse Translational Study of Path Integration. [PDF]

Hippocampus
Duncan S, Rehman S, Segen V, Choi I, Lawrence S, Kalani O, Gold L, Goldman L, Ramlo S, Stickel K, Layfield D, Wolbers T, Tiganj Z, Newman EL.   +13 more
europepmc   +1 more source

Mental health impacts experienced by caregivers of people with Dravet syndrome: A systematic literature review

Epilepsia, EarlyView.
Graphical abstract for the systematic literature review. Abstract Objective Dravet syndrome (DS) places tremendous burden on caregivers owing to the extent of required assistance and impact on daily living, as well as the risk to the individual with DS of premature mortality from sudden unexpected death in epilepsy and morbidity associated with ...
Adam Strzelczyk, Mary Anne Meskis, Galia Wilson, Bobby Jacob, Christoph Helmstaedter, Jane von Gaudecker, Veronica Hood, Ceri Hughes, Michael Scott Perry   +8 more
wiley   +1 more source

Autism outcomes and neurobehavioural markers in young children born to mothers with HIV in Kenya: a protocol for the Alama project. [PDF]

BMJ Open
Oyungu E, Keehn B, McHenry MS, Monahan PO, Joseph RM, Yoon SY, Carlucci JG, Saina C, Khaitan A, Baliddawa J, McNally Keehn R.   +10 more
europepmc   +1 more source

Anthropologist, heal thyself: Toward an anthropology of healing through relational interbeing

Feminist Anthropology, EarlyView.
Abstract I call for an anthropology that confronts its own woundedness. Anthropologists often bear witness to suffering but rarely examine how our own grief, trauma, and institutional distress shape the affective tone of our work. Drawing on fieldwork with Runa (Quechua) women affected by forced sterilization in Peru and guided by my collaborator and ...
Lucía Isabel Stavig
wiley   +1 more source

"Just Stay Home and Wait It Out": Exploring Challenges Accessing Care for Miscarriage in Indiana. [PDF]

Perspect Sex Reprod Health
LaRoche KJ, Maldonado Quiles A, Fafowora OJ, Lawal F.   +3 more
europepmc   +1 more source

Pandemic Im/mobilities, reproductive injustices, and assisted reproductive technology use among Taiwanese LGBTQ parents

Feminist Anthropology, EarlyView.
Abstract This article examines how mobility restrictions imposed by governments during the COVID‐19 pandemic intensified reproductive and mobility injustices. It traces shifting configurations of privilege and inequality within marginalized groups whose reproductive desires remain legally and socially unrecognized.
Sara L. Friedman
wiley   +1 more source