Results 151 to 160 of about 1,228,020 (262)

A practical approach for health system leaders to implement early detection of mild cognitive impairment and dementia in primary care. [PDF]

BMC Prim Care
Willis DR, Fowler NR, Brosch JR, Summanwar D, Hammers DB.   +4 more
europepmc   +1 more source

A priori bounds for the generalised parabolic Anderson model

Communications on Pure and Applied Mathematics, EarlyView.
Abstract We show a priori bounds for solutions to (∂t−Δ)u=σ(u)ξ$(\partial _t - \Delta) u = \sigma (u) \xi$ in finite volume in the framework of Hairer's Regularity Structures [Invent Math 198:269–504, 2014]. We assume σ∈Cb2(R)$\sigma \in C_b^2 (\mathbb {R})$ and that ξ$\xi$ is of negative Hölder regularity of order −1−κ$- 1 - \kappa$ where κ<κ¯$\kappa <
Ajay Chandra, Guilherme de Lima Feltes, Hendrik Weber   +2 more
wiley   +1 more source

An IQ Consortium Perspective on the FDA Guidance for Assessment of Pharmacokinetics in Participants With Impaired Renal Function

Clinical Pharmacology &Therapeutics, EarlyView.
The FDA published guidance on assessing pharmacokinetics (PK) in participants with impaired renal function in 2024. The IQ CPLG Organ Impairment Working Group summarized the industry’s perspective on this guidance by highlighting a few key updates in the 2024 guidance, including: (1) the recommendation of using estimated glomerular filtration rate ...
Yan Jin, Ashish Sharma, Mariam A. Ahmed, Sravanthi Cheeti, Ying Ou, Damayanthi Devineni, Yizhe Chen, Jitendra S. Kanodia, Yasmeen Abouelhassan, Nadia Noormohamed, Jin Zhou, Patrick Marroum, Vaishali Sahasrabudhe, Islam R. Younis   +13 more
wiley   +1 more source

Longitudinal Tumor Size and Survival Modeling for Exposure–Response Analysis of Drugs with Frequent Dose Reductions: Dose Justification of Abemaciclib in Patients with Metastatic Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Abemaciclib is an oral anticancer drug indicated for treatment of HR+ HER2‐ breast cancer. Dose modifications due to side effects are frequent, thus drug exposures change over time as a result of altering the dose or temporarily withholding abemaciclib treatment.
Emmanuel Chigutsa, Sonya C. Chapman, P. Kellie Turner   +2 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Steroidogenic Factor 1 (SF1) Immunohistochemical Stain Is Sensitive and Specific for the Cytopathologic Identification of Intrapancreatic Ectopic Splenic Tissue

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Accessory spleens result from failure of splenic fusion during development and are occasionally located in the pancreatic tail, radiographically appearing as solid or solid/cystic lesions. Fine needle aspiration (FNA) easily identifies accessory spleens in most samples based on architecture and using CD8 to highlight splenic ...
Adeyinka Akinsanya, Jessica L. Muldoon, Mohamed Mustafa, Bin Yang, Hector Mesa, Omer Saeed   +5 more
wiley   +1 more source

Investigations Into the Human Metabolism of Trestolone (7α‐Methyl‐19‐Nortestosterone)

Drug Testing and Analysis, EarlyView.
As the known metabolites of 7α‐methyl‐19‐nortestosterone (MENT), M1 and M2, suffer from chromatographic issues under routine doping control conditions, the human metabolism of MENT was reinvestigated. From the numerous new metabolites detected, especially, M5 and M10 were identified as the most promising candidates to be implemented into routine ...
Thomas Piper, Gregor Fusshöller, Mario Thevis   +2 more
wiley   +1 more source

Reviewing Research on Transgender and Nonbinary People in Social Psychology: Insights and Future Research Directions

European Journal of Social Psychology, EarlyView.
ABSTRACT Transgender and nonbinary (TGNB) identities and issues faced by TGNB people are receiving growing attention in social psychology. At the same time, this is a relatively new area, and most research on LGBTQ+ issues primarily focuses on sexual minorities, whereas most research on gender focuses on women and men.
Thekla Morgenroth, Kira Kay Means
wiley   +1 more source

RAZOR: a database of PCR primers targeting human respiratory viruses. [PDF]

NAR Genom Bioinform
Gill HM, Mir Q, Srivastava R, Janga SC.
europepmc   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source