Development of novel aptamers for low-density lipoprotein particle quantification. [PDF]
PLoS ONE, 2018 Cardiovascular disease (CVD) remains the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) is commonly used for CVD risk assessment; however, recent research has shown LDL particle (LDL-P) number to be a more sensitive ...
Daniel Klapak +4 more
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Wellbeing of Alcohol-preferring Rats Euthanized with Carbon Dioxide at Very Low and Low Volume Displacement Rates [PDF]
, 2019 The 2013 AVMA Guidelines on Euthanasia recommend the use of very-low or low flow rates of 100% carbon dioxide to euthanize small rodents. Although inhalation of high concentrations of carbon dioxide are generally recognized as painful in humans, whether ...
Hickman, Debra L.
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pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells [PDF]
, 2019 Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding.
Korzhikov-Vlakh, Viktor +7 more
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Strong binding and fluorescence sensing of bisphosphonates by guanidinium-modified calix[5]arene
Beilstein Journal of Organic Chemistry, 2018 Based on the indicator displacement assay (IDA) approach, we herein report the fluorescence “switch-on” sensing and quantitative detection of bisphosphonates (BPs), a class of drugs extensively used in the treatment of patients with various skeletal ...
Jie Gao +5 more
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BMC Microbiology, 2021 Background Tuberculosis (TB) is a serious chronic infectious disease caused by Mycobacterium tuberculosis complex (MTBC). Hence, the development of a novel, simple, rapid and sensitive method to detect MTBC is of great significance for the prevention and
Junfei Huang +9 more
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Molecules, 2021 Novel indolocarbazole derivatives named LCS were synthesized by our research group. Two of them were selected as the most active anticancer agents in vivo.
Roman G. Zenkov +12 more
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A mathematical model quantifies proliferation and motility effects of TGF--$\beta$ on cancer cells [PDF]
, 2008 Transforming growth factor (TGF) $\beta$ is known to have properties of both a tumor suppressor and a tumor promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell--cell adhesion.
Arteaga, Carlos L. +6 more
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Use of mathematical derivatives (time-domain differentiation) on chromatographic data to enhance the detection and quantification of an unknown 'rider' peak [PDF]
, 2003 Two samples of an anticancer prodrug, AQ4N, were submitted for HPLC assay and showed an unidentified impurity that eluted as a 'rider' on the tail of the main peak.
Elliott, M A, Ford, S J, Halbert, G W
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Supramolecular fluorescence biosensing based on macrocycles
Supramolecular MaterialsFluorescence sensing converts chemical events into measurable readings by utilizing fluorescence signals for the qualitative or quantitative detection of specific analytes.
Jia-Hong Tian +3 more
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Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water. [PDF]
, 2018 The selective detection of citrate anions is essential for various biological functions in living systems. A quantitative assessment of citrate is required for the diagnosis of various diseases in the human body; however, it is extremely challenging to ...
Alamgir, Azmain +7 more
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