Results 81 to 90 of about 369,778 (264)

Macrophyte community structure across Serbian water-body types: foundations for developing bioassessment tools

Frontiers in Environmental Science
Macrophytes are widely used as biological quality elements in ecological assessment, yet the extent to which they reflect water-body typology remains insufficiently evaluated in Serbia.
Dragana Vukov, Mirjana Ćuk, Miloš Ilić   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Reef Check Med Dataset on Key Mediterranean Marine Species 2001–2020

Frontiers in Marine Science, 2021
Eva Turicchia, Eva Turicchia, Eva Turicchia, Eva Turicchia, Eva Turicchia, Massimo Ponti, Massimo Ponti, Massimo Ponti, Massimo Ponti, Gianfranco Rossi, Carlo Cerrano, Carlo Cerrano, Carlo Cerrano, Carlo Cerrano, Carlo Cerrano   +14 more
doaj   +1 more source

Influencing Factors and Assessment of River Habitat Health

Renmin Zhujiang, 2020
As an important part of the river ecosystem, the river habitat plays avital role in the river ecosystem. Based on a summary of the stress on riverecosystems caused by a series of human activities such as water conservancyprojects, this paper introduces ...
FENG Yingying, JI Yong, LIU Xingchen, YAN Ruyu, YANG Junfei, ZHANG Yue   +5 more
doaj  

Caddisflies (Trichoptera) of Protected Calcareous Fen Habitats: Assemblages, Environmental Drivers, Indicator Species, and Conservation Issues. [PDF]

Insects, 2023
Buczyńska E, Tarkowski A, Sugier P, Płaska W, Zawal A, Janicka A, Buczyński P.   +6 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Constructing indicator species distribution models to study the potential invasion risk of invasive plants: A case of the invasion of Parthenium hysterophorus in China. [PDF]

Ecol Evol, 2023
Liu J, Wei H, Zheng J, Chen R, Wang L, Jiang F, Gu W.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Warm‐Water Regimes Influence Microbial Diversity and Ecological Functions in Subtropical Gulf

Ecology and Evolution
The marine ecosystem is a key biogeochemical engine driven by complex hydrodynamic processes and harbors significant microbial abundance and diversity. However, the influence of warm‐water dynamics on marine microbial community composition and ecological
Qing He, Laizhen Huang, Chongqiu Huang, Rajapakshalage Thashikala Nethmini, Jannatul Ferdoush, Shengyao Zhou, Gonglingxia Jiang, Qinghua Hou, Xiaolei Li, Qingxiang Chen, Ke Dong, Lingling Xie, Nan Li   +12 more
doaj   +1 more source