Results 251 to 260 of about 1,225,552 (316)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Overcrowding Indicators in Emergency Departments Across Countries: Scoping Review. [PDF]

Interact J Med Res
Mohd Nasir NN, Indera Putera KAS, Noris NJ, Libasin Z, Krishnan M, Salaton NF, Lum KY, Abdullah NNR, Saimy IS.   +8 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Joint Associations of Cumulative C-Reactive Protein-Triglyceride-Glucose Index and Depression with Cardiovascular Outcomes in Middle-Aged and Older Adults: A National Prospective Cohort Study. [PDF]

Glob Heart
Tu Q, He Z, Duan Y, Jiang X, Dong H, Zou Y.   +5 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Optimization of Moving Cone Liner Dynamics and Health Status Prediction for Cone Crushers. [PDF]

Sensors (Basel)
Li M, Fu R, Wu D, Zhao L.
europepmc   +1 more source

Development of an Evaluation Index System for Chinese Medicine Specialist Nurse Training Effectiveness: A Delphi-AHP Study. [PDF]

J Multidiscip Healthc
Qi Y, Li H, Mao J, Yu F, Chen Y, Zhong Y, Lu J, Gu Y, Zhang W.   +8 more
europepmc   +1 more source

Construction of a public health emergency information system framework: A case study of Zhuhai city, China. [PDF]

PLoS One
Huang S, Zhang X, Chen L, Ni X, Fan Y, Zhao C, Xiao J, Ruan F.   +7 more
europepmc   +1 more source

Balance Disorders: Insufficient Supply of Vestibular Examinations by the Italian National Health Service, 2021-2023. [PDF]

Healthcare (Basel)
Bubbico L, Mastrangelo G, Barbone F, Cegolon L.   +3 more
europepmc   +1 more source

The predictive value of multidimensional frailty instruments for postoperative adverse outcomes in cancer patients: a systematic review and meta-analysis. [PDF]

World J Surg Oncol
Chen Y, Song S, Wang Z, Guo Y, Fu Z, Xu T, Chen Y, Jiang Z, Ding L, Xu Q.   +9 more
europepmc   +1 more source