Results 121 to 130 of about 4,980,966 (341)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response [PDF]

, 2023
Tijana Randic, Stefano Magni, Demetra Philippidou, Christiane Margue, Kamil Grzyb, Jasmin Renate Preis, Joanna Wróblewska, Petr V. Nazarov, Michel Mittelbronn, Katrin Frauenknecht, Alexander Skupin, Stephanie Kreis   +11 more
openalex   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Are Green Buildings an Indicator of Sustainable Development? [PDF]

, 2023
Antonio Marotta, César Porras-Amores, Antonio Rodríguez Sánchez   +2 more
openalex   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

New performance indicators for industrial symbiosis: an ecosystem approach [PDF]

, 2017
This paper proposes new performance indicators for industrial symbiosis networks (ISNs) based on the ecosystem approach. ISNs are framed as ecosystems where the firms correspond to the organisms and perform specific functions, i.e ...
Fraccascia, Luca, Ilaria, Giannoccaro, Vito, Albino   +2 more
core  

Crime prediction through urban metrics and statistical learning

, 2018
Understanding the causes of crime is a longstanding issue in researcher's agenda. While it is a hard task to extract causality from data, several linear models have been proposed to predict crime through the existing correlations between crime and urban ...
Alves, Luiz G A, Ribeiro, Haroldo V, Rodrigues, Francisco A   +2 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Analysis Of The Cognitive Content Of Two Types Of Swimming According To Content Organization Indicators And Their Impact On Technical Performance And Achievement

Indonesian Journal of Physical Education and Sport Science
Study purpose. University curricula need continuous review, analysis, change, and development due to their strong association with methodological variables.
Muhammad Suhail Najm Al-Hamdani, Doaa Subhan Mahmoud Al-Zuhairi   +1 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source